Protein Alignment mnb and dyrk2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_005164697.1
• Gene: dyrk2 / 557602
• ZFINID: ZDB-GENE-030131-2804
• Length: 598
• Species: Danio rerio
• Alignment Length: 479
• Identity: 182/479 - (37%)
• Similarity: 260/479 - (54%)
• Gaps: 85/479 - (17%)

  Fly   213 SSSEVRAMQARIPNHFREPASGPL----------RKLSVDLIKTYKH-----INEVYY----AKK 258
            ||:.:::.:::       |...||          .||||     ::|     ..|:|:    |||
Zfish   136 SSTSIKSTESK-------PKPAPLTPEQAMKQYMSKLSV-----FEHQEILSYTEIYFIGPNAKK 188

  Fly   259 KRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDH 323
            :      ||....||       |.|||||...||....:....|||:..:|||||||||||||||
Zfish   189 R------QGVVGGSN-------NGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDH 240

  Fly   324 EEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYN 388
            :...|||:|:::|:|.|..||..|:::||.:.:.|.::...::.:..:|.:|||:|:.|||||.|
Zfish   241 KNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMN 305

  Fly   389 LYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFG 453
            ||:|::...|:|.||.|.||||..:...|  .|..:..|||||||||||||....||.||::|||
Zfish   306 LYELIKKNKFQGFSLPLVRKFAHSILQCL--ESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFG 368

  Fly   454 SSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIV 518
            |||...||:|.||||||||:|||:||.:|.:.||||||||||.|:.||.||..|.:|.||:..::
Zfish   369 SSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVI 433

  Fly   519 EVLGMPPKYLLDQAHKTRKFFDK----------IVADGSYVLK--KNQNGRKYKPPGSRKLHDIL 571
            |:||||.:.||:.:.:.:.|...          .:.|.|.||.  :::.|:...|||||.....|
Zfish   434 EMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTAL 498

  Fly   572 GVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKR----------T 626
                     :..|:|        .|.|.:.:.|::||..|:||..||:|.:.:|          |
Zfish   499 ---------KGCDDP--------LFLDFLKQCLEWDPSQRMTPSQALRHPWLRRRLPKPPTEKTT 546

  Fly   627 ADEATNTSGAGATANAGAGGSGSS 650
            ....|..:||..:.:.....|||:
Zfish   547 VKRITEGTGAITSISKLPPPSGSA 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	151/360 (42%)
dyrk2	XP_005164697.1	PKc_DYRK2_3	154..533	CDD:271126	169/415 (41%)