Protein Alignment mnb and hipk2

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001093455.3
• Gene: hipk2 / 557551
• ZFINID: ZDB-GENE-031125-4
• Length: 1228
• Species: Danio rerio
• Alignment Length: 1125
• Identity: 274/1125 - (24%)
• Similarity: 419/1125 - (37%)
• Gaps: 328/1125 - (29%)

  Fly   132 VDGNVLMVQGSSSSSSRMKAERALYY--------TMSAYGSSG------GSVDAAQGSGSGG-GR 181
            ::|..|.|     |:|.:..|:||.:        ..||..:||      ||. .:.|||||| ..
Zfish    66 INGASLQV-----SNSSLSYEQALLFPAGSGHIVVASASSTSGAAGQLLGST-GSSGSGSGGHNL 124

  Fly   182 QRHAPLYGRFVDAEDLPATHR--DVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLI 244
            .|.:.:  ..:|........|  :.:.:::...|.|.|..::.:.|     ||  |:.:.:|...
Zfish   125 TRRSTV--SLLDTYQRCGLKRKSEELDNNNGSGSGSSVHVVEEQQP-----PA--PMIQNNVQSG 180

  Fly   245 KTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLI 309
            .|.........|..|.....::||               |....|:.:.    ...:.||:...:
Zfish   181 ATVATATASTTATSKNSGANSEGD---------------YQLLQHEVLC----SMTNTYEVLEFL 226

  Fly   310 GKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMW 374
            |:|:||||||.:.......|||||:||...:..|.||||.:|..::...|:: |..|:....|..
Zfish   227 GRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQH 290

  Fly   375 RNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILL 439
            :||.|||||:|..||||.|:...|..:.|...|...||:.|||:.|.:  |.:||.|||||||:|
Zfish   291 KNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS--LGLIHADLKPENIML 353

  Fly   440 CNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTG 501
            .:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::||:.:..|||||||||::.|:..|
Zfish   354 VDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLG 418

  Fly   502 EPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVL--------------KK 552
            .||:.|.:|.||:..|.:..|:|.:|||....||.:||:: ..|.:|.|              .|
Zfish   419 WPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR-DPDSTYPLWRLKTPEDHEAETGIK 482

  Fly   553 NQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPY 615
            ::..|||.   ...|.|:  :.:.|...|...|.|.    :|..:|.||:.:||..|...|:||.
Zfish   483 SKEARKYI---FNCLDDMAQVNMTTDLEGSDMLAEK----ADRREFIDLLTKMLTIDADKRITPI 540

  Fly   616 YALQHNFF------------------------KRTAD--EATNTSGAGATANAGAGGSGS----- 649
            ..|.|.|.                        ||..:  :..|.|......:.....|.:
Zfish   541 ETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTF 605

  Fly   650 --------SGAGGSSGGGVGGGLGASNSSSGAVSSSSA-----AAPTAATAAAT----------- 690
                    |.|...:.......|..:|.....::..||     |||.||.|..|
Zfish   606 NNQLNTVHSQATNLAPSSTSATLSLTNPDVSILNYQSALYQPSAAPMAAVAPRTMPLQPGAPQLC 670

  Fly   691 ----------------------AAGSSGSGSSVGGGSSAAQQQQAMPL----PLPLPLPLPP--- 726
                                  |:.|..:|.||       :.:.|:|:    |...||.:.|
Zfish   671 AARPDPFQQALIVCPPGFQGLQASPSKHTGYSV-------RMENAVPIVTQAPGAQPLQIQPGLL 728

  Fly   727 --LAGPGG--------ASDGQCHGLLMH-SVAANAMNNFSALSLQSNAHP----------PPSLA 770
              .|.|.|        |.....|..:.| :|..::|.:...|:...|:||          .|:|.
Zfish   729 TQQAWPSGTQQILLPPAWQQLTHTSVQHATVIPDSMTSSQPLANWRNSHPHGSHYNPIMQQPALL 793

  Fly   771 NSHHSTNSLGSLN----HI--SPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNH 829
            ..|.:......||    |:  .|      :||.::|..|.:|.    .|..|:.|:..|.:....
Zfish   794 AGHVTLPPQQPLNVGVAHVMRQP------SNNQSNSKKNKQHQ----MNNRNVSGYDVSSTQPVT 848

  Fly   830 NSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAA 894
            :........|..||:.              |::|..|.|
Zfish   849 SPQRSKRVKENTPPRC--------------AVVQNGPPS-------------------------- 873

  Fly   895 AASHLMMTDSSVISASAAGGGQGG--------GNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSL 951
                     :.|.|.:..|||.||        .:.||:  .|.....:.|..|:..:....:.|.
Zfish   874 ---------TCVPSQTCTGGGWGGEQACSTTRDHHGQH--NPPRQTIIIPDTPSPAVSIITISSD 927

  Fly   952 SDLPLPMPLPMS--------------VPLQLPPSSSSSVSS----GSASVGSGGVGV---GVV-- 993
            :|....:..|.:              |.:...|.|.||.:|    .|.:.|....|.   |.|
Zfish   928 TDEEDDLKQPTNTSTSSKQRKNVISCVTVHDSPDSDSSNTSPYAVDSRTNGPNANGYDSKGAVLD 992

  Fly   994 ----GQRRHITGPAAQVGISQSVG---------------------------SG---SSGSATGAS 1024
                |..|.|..|..:...|:::|                           ||   :||..||..
Zfish   993 NYSNGNPRTIIIPPLKSQTSENLGECDRLLPADVMNHQNSTYKFKTSNGGFSGNNHTSGGVTGGG 1057

  Fly  1025 SSDASSSSPMVGVCVQQNPV 1044
            :.....:.|..   .||.|:
Zfish  1058 AYRQQRTGPHP---FQQQPL 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	133/381 (35%)
		S_TKc	303..623	CDD:214567	129/338 (38%)
hipk2	NP_001093455.3	STKc_HIPK	220..548	CDD:271113	129/338 (38%)
		S_TKc	220..548	CDD:214567	129/338 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.770