Protein Alignment mnb and dyrk1b

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_005158271.1
• Gene: dyrk1b / 556212
• ZFINID: ZDB-GENE-060503-499
• Length: 833
• Species: Danio rerio
• Alignment Length: 1008
• Identity: 459/1008 - (45%)
• Similarity: 550/1008 - (54%)
• Gaps: 252/1008 - (25%)

  Fly    79 VRNWPTN---GNQDQADDDDAGHQIISKFLPKSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQ 140
            |.|.||.   |:.||           ::|||:|                          ::|...
Zfish    18 VANLPTESWIGSPDQ-----------NRFLPQS--------------------------HLLRKP 45

  Fly   141 GSSSSSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVM 205
            ..|.|||..|...:.....:|.|                           |..||...::
Zfish    46 ARSGSSSGCKPPSSTLCQPAALG---------------------------FSPAEPTMSS----- 78

  Fly   206 HHHSSPSSS------------SEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKK 258
             .||.||.|            |::..:|.|||..||:|||.|||||||||||||||||||||.||
Zfish    79 -QHSHPSFSNIHSMADQQQVLSDMTILQRRIPPSFRDPASAPLRKLSVDLIKTYKHINEVYYTKK 142

  Fly   259 KRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDH 323
            ||||||.. .:|||.|||||:|||||||||:|||:|||||:||||||||||||||||||||||||
Zfish   143 KRRAQQVP-PEDSSTKKERKVYNDGYDDDNYDYIVKNGEKWLDRYEIDSLIGKGSFGQVVKAYDH 206

  Fly   324 EEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYN 388
            .||..||||||||||.||||||||::|||:||:.|.|.|||||.||||||:||||||||||||||
Zfish   207 HEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYN 271

  Fly   389 LYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFG 453
            ||||||||||||||||||||||||||||||||:||||:|||||||||||||||||||||||||||
Zfish   272 LYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFG 336

  Fly   454 SSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIV 518
            ||||||||||.|||||||||||||||:.||||||||||||||||||||||||||.||||||||||
Zfish   337 SSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIV 401

  Fly   519 EVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRK--------YKPPGSRKLHDILGVET 575
            ||||:||.::||||.|.||:|||: :||.:.:|||::.:|        ||||.:|:||:||||||
Zfish   402 EVLGVPPNHMLDQAPKARKYFDKL-SDGLWTVKKNKDIKKVLYPSASEYKPPATRRLHEILGVET 465

  Fly   576 GGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATA 640
            |||||||..|.||:..||||||||||||||:|||||:||:|||||||||:|.||.||||  .:|:
Zfish   466 GGPGGRRAGEQGHAPCDYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDEGTNTS--SSTS 528

  Fly   641 NAGAGGSGSSGAGGSSGGGVGGGLGASNSS----------SGAVSSS-----SAAAPTAATAAAT 690
            .:.|.....|.:..||....||..|:||.:          :.||:.:     |..||:.......
Zfish   529 TSPAMDHSHSTSTTSSVSSSGGSSGSSNDNRNYRYSNRYYNSAVTHTDYEMQSPQAPSQQQLRIW 593

  Fly   691 AAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFS 755
            ..|.|..|.....||.::..|                             ||:|..||
Zfish   594 PGGDSSMGQLSNSGSDSSYPQ-----------------------------LLLHKPAA------- 622

  Fly   756 ALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGH 820
                            :.||.:.||::.    |....|:.:.           :|||       |
Zfish   623 ----------------TQHSRHFLGNIG----GMMEPHHPHP-----------IYGS-------H 649

  Fly   821 HNSGSS--NNHNSISYPHAMECDPPQ----MPPPPP----------NGHGRMRVPAIMQLQPNSY 869
            |::|..  ......:.|........|    ||...|          ..|..:...:|||..|:|.
Zfish   650 HSNGRQLRQQQQQQNQPQGQASQGQQGTALMPVSSPQMQDSIELSLTHHHHLGQSSIMQPPPSSL 714

  Fly   870 APNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFL 934
            ..:.   ||   ||::            ||.::.....:..|.          |.|  |||:...
Zfish   715 DSSQ---YG---SSNL------------HLGLSAFRTRTVMAP----------QQP--PSASQQQ 749

  Fly   935 FPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVG---SGGV---GVGVV 993
            .|..||......|...|..:|         |.....:::::...||..||   :||.   |||..
Zfish   750 LPQAPASQDSMVAASGLGYIP---------PCYAGSNNNNNPPQGSVGVGAMLTGGPPPRGVGGA 805

  Fly   994 GQRRHITGPAAQVGISQSVGSGSSGSATGASSS 1026
            |.|     |.::.....:|....|||...|::|
Zfish   806 GGR-----PDSEESSMMAVCGSGSGSGQSAANS 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	284/346 (82%)
dyrk1b	XP_005158271.1	PKc_DYRK1	175..518	CDD:271128	282/343 (82%)