Protein Alignment mnb and clk4b

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001316837.1
• Gene: clk4b / 503607
• ZFINID: ZDB-GENE-050227-19
• Length: 479
• Species: Danio rerio
• Alignment Length: 471
• Identity: 147/471 - (31%)
• Similarity: 214/471 - (45%)
• Gaps: 94/471 - (19%)

  Fly   181 RQRHAPL-YGRF---VDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSV 241
            |.|.|.| :.|:   ||........:|..|:..|.|..|. |:.:||..:|.|.|.|
Zfish    67 RAREASLEHSRYKGRVDPVRETEREKDGYHYSQSRSGRSR-RSSRARQHSHHRSPGS-------- 122

  Fly   242 DLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEID 306
                                      |..|..:|..|...|  |::.| .:..||:....||||.
Zfish   123 --------------------------DSRSHRRKRTKSIED--DEEGH-LVYHNGDMLRARYEIV 158

  Fly   307 SLIGKGSFGQVVKAYDHEE-QCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKR 370
            ..:|:|:||:||:..||.: ...||:|||||.:.:...|..||.:||.:|..|.|.::..|::..
Zfish   159 GTLGEGAFGKVVECLDHTKGNVRVALKIIKNIERYREAALSEVDVLERINSLDDEKRFACVRMLD 223

  Fly   371 HFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPE 435
            .|....|:|:|||||..:.||.|:...|...||...|..|.|:..|:.||...:|.  |.|||||
Zfish   224 WFDHHGHICIVFELLGLSTYDFLKENGFMPFSLTQIRHMADQIFRAVRFLHKNKLT--HTDLKPE 286

  Fly   436 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYD 483
            |||..:.                 ||..:|:||||::....:.....:.:|.||:|||:|.:.::
Zfish   287 NILFVDSNYDIKYNSRMKRDERTLKRLDVKVVDFGNATYDHEHHTSVVSTRHYRAPEVILELGWN 351

  Fly   484 LAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTR-KFFDKIVAD-- 545
            .|.|:|||||||||.:.|..||...:..:.:..:.:|||..|.:||.:..|.| ...||:..|
Zfish   352 QACDVWSLGCILVEFYLGLTLFQTHDSKEHLAMMEKVLGPIPTHLLQKTKKRRYVHHDKLDWDEH 416

  Fly   546 ---GSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFD 607
               |.||       ||:..|    |...:..:|          |.|.    |.| ||:.:|:::|
Zfish   417 SSAGRYV-------RKHCKP----LKQYMSSKT----------PEHE----LLF-DLLQKMMEYD 455

  Fly   608 PKTRVTPYYALQHNFF 623
            ...|:|...|:.|.||
Zfish   456 SSKRITLEQAIGHPFF 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	122/359 (34%)
clk4b	NP_001316837.1	Protein Kinases, catalytic domain	142..471	CDD:473864	120/357 (34%)