DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnb and dyrk3

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_012815970.1	Gene:	dyrk3 / 493520	XenbaseID:	XB-GENE-1008699	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	184/498 - (36%)
Similarity:	260/498 - (52%)	Gaps:	78/498 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 SSPSSSSEVRAMQARIPNHFREPASGPLRKLSVD-LIKTYKH------------INEVYY----A 256
            :|.||.|..::.:|..              |:.| .:|.|||            .:|:|:    |
Frog   106 TSKSSDSSAKSSKATY--------------LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNA 156

  Fly   257 KKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAY 321
            ||:      ||.....|       |.|||||...|.:...:....|||:..:|||||||||.|.|
Frog   157 KKR------QGVVGGPN-------NGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVY 208

  Fly   322 DHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLS 386
            ||:...|:|:|:::|:|.|..||..|:::||.:.:.|......::.:...|.:|||:|:.|||||
Frog   209 DHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLS 273

  Fly   387 YNLYDLLRNTNFRGVSLNLTRKFAQQL--CTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKI 449
            .|||:|::...|:|.||.|.||||..:  |...|:.:    .|||||||||||||....||.||:
Frog   274 MNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRN----KIIHCDLKPENILLKQQGRSGIKV 334

  Fly   450 VDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQM 514
            :||||||...||:|.||||||||:|||:||.:|.:.|||||.||||||:.||.|||.|.:|.||:
Frog   335 IDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQL 399

  Fly   515 NKIVEVLGMPPKYLLDQAHKTRKFFDK----------IVADGSYVLKKNQNGRKYKPPGSRKLHD 569
            ..::|:||.||..||:||.:.:.|.:.          .:.:|:.||    ||.:     ||:
Frog   400 ACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVL----NGSR-----SRR--- 452

  Fly   570 ILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF-KRTADEATNT 633
              |...|.||.:..........|.| |.|.:...|.:||..|:||..||:|.:. ||....:...
Frog   453 --GKMRGAPGSKDWVAALKGCEDSL-FIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSVTE 514

  Fly   634 SGAGATANAGAGGSGSSGAGGSSGGGVGGGLGAS--NSSSGAV 674
            ..:|...::........|:......||...|.|:  |.|:|::
Frog   515 KASGKRISSQTSSFPGIGSKLPPVVGVANKLRANLMNDSNGSI 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	150/351 (43%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	146/331 (44%)
dyrk3	XP_012815970.1	PKc_DYRK2_3	124..503	CDD:271126	167/410 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950