DRSC/TRiP Functional Genomics Resources

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Protein Alignment mnb and Doa

DIOPT Version :10

Sequence 1:NP_728107.2 Gene:mnb / 32771 FlyBaseID:FBgn0259168 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_001014681.2 Gene:Doa / 43415 FlyBaseID:FBgn0265998 Length:2045 Species:Drosophila melanogaster


Alignment Length:520 Identity:143/520 - (27%)
Similarity:231/520 - (44%) Gaps:102/520 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 DAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASG 234
            :|:.|.|.||..       |...|    |.|:..:.  ::||:|||..:  |.:.|...::....
  Fly  1579 NASAGGGGGGAA-------GLQYD----PNTNTQLF--YASPASSSSNK--QPQQPQQQQQQQQS 1628

  Fly   235 PLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLY---------NDGYDDDNHD 290
            .|::           .|.|.:....::.|..|...:..:|....|:         .|  |.|.| 
  Fly  1629 QLQQ-----------SNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQD--DADGH- 1679

  Fly   291 YIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMN 355
            .|...|:....||:|.:.:|:|:||:|||..|.|....:|:|||||.:.:...|::|:..||.:.
  Fly  1680 LIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIA 1744

  Fly   356 RADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFL 420
            :.|....:..||:...|.:..|:|:|||:|..:::|.||..|:....|:..|..|.|||.::.||
  Fly  1745 QKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFL 1809

  Fly   421 STPELNIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQS 468
            ....|.  |.||||||||..:.                 |.:.::::||||:....:.....:.:
  Fly  1810 HDNRLT--HTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVST 1872

  Fly   469 RFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAH 533
            |.||:|||:|.:.:....|:||:||||.|::.|..||...:..:.:..:..:||..| |.:.:.|
  Fly  1873 RHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIP-YRMARNH 1936

  Fly   534 ------KTRKFF------DKIVADGSYVLKKNQNGRKY-KPPGSRKLHDILGVETGGPGGRRLDE 585
                  ||:.|:      |:..:.|.||       |.: ||....:|.|                
  Fly  1937 TLYSKTKTKYFYHGKLDWDEKSSAGRYV-------RDHCKPLFLCQLSD---------------- 1978

  Fly   586 PGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSGSS 650
                ..|:.:...||.:||:::|.:|:|...||.|.||.|....    ...|..:|.....||||
  Fly  1979 ----SEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPH----HRVGEVSNKQPLSSGSS 2035

  Fly   651  650
              Fly  2036  2035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mnbNP_728107.2 PKc_DYRK1 289..628 CDD:271128 111/368 (30%)
DoaNP_001014681.2 PHA03247 <205..634 CDD:223021
PKc_CLK 1679..2012 CDD:271036 108/363 (30%)
Blue background indicates that the domain is not in the aligned region.

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