DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and prpf4ba

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_017207374.1	Gene:	prpf4ba / 393182	ZFINID:	ZDB-GENE-040426-947	Length:	986	Species:	Danio rerio

Alignment Length:	588	Identity:	165/588 - (28%)
Similarity:	248/588 - (42%)	Gaps:	148/588 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 RDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAP----- 186
            |:|||:|....:...|.....|...||.               |..:||.|.|.:.....
Zfish   454 RERDRMDRRQPVRSRSQERRRRRSKERE---------------DMFKGSLSEGMKAEQEDSDEEV 503

  Fly   187 LYGRFVDAEDLPA----------------------THRDVMHHHSSPSSSSEVRAMQARIPNHFR 229
            |....||.||..|                      ::...:..|.||.||:           |.|
Zfish   504 LEDYDVDEEDEEALIEQRRLQRLAIMQKYKPVNEDSNMSGLSDHGSPQSST-----------HSR 557

  Fly   230 EPASGP-LRKLSVDLIKTYKHIN--------EVYYA----------KKKRRAQQ--TQGDD---- 269
            .|:... |.:::.| :|.|:..|        :..|:          .||..|..  |:.||
Zfish   558 SPSPDDILERVAAD-VKAYEQENLDTFEDNVKAKYSLVSQEKNGANSKKPPAPDMFTESDDMFAA 621

  Fly   270 --DSS---------NKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYD- 322
              ||:         :.||.....|.:.|....|.:..||....||.:....|:|.|..|::|.|
Zfish   622 YFDSARLRAAGIGKDFKENPSLRDNWTDAEGYYRVNIGEVLDKRYAVYGYTGQGVFSNVIRARDL 686

  Fly   323 ---HEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFEL 384
               ::|   ||:|||:|.:........|::.|:.:|.|||::|::.::|.|||..:.|||||||.
Zfish   687 ARANQE---VAVKIIRNNEMMQKTGLKELEFLKKLNDADADDKFHCLRLFRHFYHKQHLCLVFEP 748

  Fly   385 LSYNLYDLLRNTNFR-GVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIK 448
            ||.||.::||..... |:.:...|.::|||..||..|.  ..||:|.|:||:|||:..|| :.:|
Zfish   749 LSMNLREVLRKYGKDVGLHIKAVRSYSQQLFLALKHLK--RCNILHADIKPDNILVNEPK-TILK 810

  Fly   449 IVDFGSSCQLGQR-IYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVD 512
            :.||||:..:... |..|:.|||||:||:::|..||..|||||:||.|.|::||:.||.|.....
Zfish   811 LCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNH 875

  Fly   513 QMNKIVEVLG-MPPKYLLDQAHKTRKF----------FDKIVADGSYVLKKNQN----------G 556
            .:...:::.| :|.|.:.....|.:.|          .||:.......:....|          |
Zfish   876 MLKLNMDLKGKLPNKMIRKGLFKDQHFDQNLNFLYTEVDKVTEREKITVMSTINPTKDLSMDMVG 940

  Fly   557 RKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHN 621
            |:..|...||       :.|                  :.|||:.::|..||..|:|...||||.
Zfish   941 RQALPEDQRK-------KVG------------------QLKDLLDQILMLDPAKRITINQALQHP 980

  Fly   622 FFK 624
            |.:
Zfish   981 FIQ 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	119/363 (33%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	114/346 (33%)
prpf4ba	XP_017207374.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810