Protein Alignment mnb and Dyrk3

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 214/617 - (34%)
• Similarity: 302/617 - (48%)
• Gaps: 120/617 - (19%)

  Fly   274 KKERKLY---NDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIK 335
            ||...:|   |..||::...||....:....|||:..:|||||||||:|||||:...|||:||::
  Fly   244 KKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVR 308

  Fly   336 NKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRG 400
            |:|.|..|||.|:::|..:.|.|..|...|:.:..:|.:|||.|:.|||||.|||:|::...|:|
  Fly   309 NEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKG 373

  Fly   401 VSLNLTRKFAQQL--CTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY 463
            .||.|.||||..|  |...|:.:    :|||||:||||:||....||.||::||||||...||||
  Fly   374 FSLQLVRKFAHSLLQCLDALYKN----DIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIY 434

  Fly   464 HYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYL 528
            .||||||||:|||:||.:|..|||||||||||.|:.:|..||.|.||.||:..|:||||||.|.:
  Fly   435 TYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNI 499

  Fly   529 LDQAHKTRKFFD----------KIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRL 583
            |..:.:::.||.          :.::||..||...|:.|              |.:.|.|..:.|
  Fly   500 LASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRR--------------GKQRGPPCSKSL 550

  Fly   584 DEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSG 648
            .:......|.| |.:.|...|::|...|:||..||:|.:.:|......               |.
  Fly   551 SKALDGCKDPL-FLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPP---------------SS 599

  Fly   649 SSGAGGSSGGGVGGGLGASNSSSGAVSSSS--AAAPTAATAAATAAG------SSGSG------- 698
            |||.||.|      ||.:|.:.|.....:.  ||..||::.:||:..      :|.|.
  Fly   600 SSGCGGVS------GLCSSRNESPVTGQNRNFAAETTASSTSATSISLTIKRENSHSSLRLHHGA 658

  Fly   699 ---------SSVGGGSSAAQQQQAMPLP-LPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNN 753
                     .||..|||.|.::..|... ||.......:..|.           .||..:..|:.
  Fly   659 VPETDFKLIKSVPEGSSTATKEPMMNSDILPESFRQTTVVSPS-----------KHSADSGGMSC 712

  Fly   754 FSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMV 818
            .||:.:..:.:.|   ..:::..|.|.|             ::.|||.|:..|  |..:..::.:
  Fly   713 LSAVDVGPSRYYP---YMNNNENNRLFS-------------SSLNSSANSLSH--LEQATKLDAL 759

  Fly   819 GHH-----------NSGSSNNHNSISYPHAME 839
            |.:           |:|.|.|..||:...|.|
  Fly   760 GEYSASTTPNLLSKNTGYSFNSGSINIDVAQE 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	155/350 (44%)
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	160/363 (44%)