DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and Hipk

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster

Alignment Length:	1063	Identity:	268/1063 - (25%)
Similarity:	405/1063 - (38%)	Gaps:	289/1063 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 TVLLDVKRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKA---ERALYYT------MSAYGSSGG 167
            |...|..|..::...:.:.:...::|....:|:|:|.:.|   .:....|      :.:|.||.|
  Fly    47 TATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHG 111

  Fly   168 -----SVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNH 227
                 ...||.|:||.|.:....|                       .|.....:.:::..   |
  Fly   112 PPVQQDSSAAAGAGSVGSKAGSGP-----------------------GPDGIGPISSLKTA---H 150

  Fly   228 FREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYI 292
            .:...||             .|.|.  ....||.:....||               |....|:.:
  Fly   151 TKVATSG-------------GHANT--QPPSKRSSSGADGD---------------YQLVQHEVL 185

  Fly   293 IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRA 357
            .....:    ||:...:|:|:||||||.:.......|||||:||...:..|.||||.:|..:::.
  Fly   186 YSLSAE----YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQE 246

  Fly   358 DAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLST 422
            :|: ::..|:....|..:||.|||||:|..||||.|:...|..:.|...|...:|:.||||.|.
  Fly   247 NAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLK- 309

  Fly   423 PELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDL 484
             :|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.: |:|||:||:||::||:.:..
  Fly   310 -QLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCE 373

  Fly   485 AIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYV 549
            |||||||||::.|:..|.||:.|.:|.||:..|.:..|:|.:::|:.|.||.|||.:.| |.:|.
  Fly   374 AIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDV-DSTYP 437

  Fly   550 ---LK-----------KNQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLDEPGHSVSDYLKFKD 598
               ||           |::..|||.   ...|.||  :.|.|...||:.|.|.    :|..:|.|
  Fly   438 FWRLKTTEEHEAETNTKSKEARKYI---FNCLDDIGQVNVPTDLEGGQLLAEK----TDRREFID 495

  Fly   599 LILRMLDFDPKTRVTPYYALQHNFFKRT--AD--EATNTSGAGATANAGAGGSGSSGAGGSSGGG 659
            |:.|||..|.:.|:||..||.|:|.:.|  .|  ...|...:.........|...:....|:
  Fly   496 LLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPAST--- 557

  Fly   660 VGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGG------GSSAAQQ-------- 710
                 ..:|....:..:.:.......|:........|...:..|      |.|.|:|
  Fly   558 -----LVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDS 617

  Fly   711 --------------QQAMPLP----------LPLPLPLPP-----------LAGPGGASDGQCHG 740
                          .|.||.|          :..||.:||           :..|   :.|| ..
  Fly   618 FQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEP---TSGQ-RM 678

  Fly   741 LLMHSVAANA---------MNNFSALSLQSNAH----PPPSLAN------SHHSTNSLGSLNHIS 786
            ||.:.|.|:.         |....:...|:.||    ....|.|      .||.......|...|
  Fly   679 LLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKES 743

  Fly   787 PGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSIS--YPHAMECDPPQMPPPP 849
            |    .|:....:|....||.:                  ..|..:|  .....|..||.
  Fly   744 P----AHHIAKGNSYRVPRHEK------------------KEHQQLSPVKKRVKESSPPH----- 781

  Fly   850 PNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMS--SSSVAAAAAAAAAAASHLMMTDSS------- 905
                 :.|......:.|..:|.::. .|||.|  |:|..:..|::||::|:::...||
  Fly   782 -----QQRYQRAAHVSPQYHAHHNC-NYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHV 840

  Fly   906 ---------------VISASAAGGGQGGG------------NPGQNPVTPSAAAFLFPSQPAGTL 943
                           ::|...|.||.||.            ..||.|...|:.......||..|:
  Fly   841 PVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITI 905

  Fly   944 YGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGSGGVGVGVVGQRRHITGPAAQVGI 1008
            :.|            |.|.:|    ...|.|....|.|    ||..|.|:.||.|
  Fly   906 HDT------------PSPTAV----ITISDSEDEGGEA----GGAQVPVLKQRAH---------- 940

  Fly  1009 SQSVGSGSSGSATGASSSDASSS 1031
            :||..|||......:||...||:
  Fly   941 AQSQTSGSLLQHAPSSSCSRSSA 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	138/359 (38%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	135/338 (40%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	135/338 (40%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870