Protein Alignment mnb and Hipk1

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_038958716.1
• Gene: Hipk1 / 365895
• RGDID: 1304941
• Length: 1216
• Species: Rattus norvegicus
• Alignment Length: 1160
• Identity: 280/1160 - (24%)
• Similarity: 432/1160 - (37%)
• Gaps: 326/1160 - (28%)

  Fly   104 FLPKSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGGS 168
            |.|.|...:.....|:...|....|          |.|.||:..        |||.|.      :
  Rat     8 FSPPSVSSSAFCSAKKLKIEPSGWD----------VSGQSSNDK--------YYTHSK------T 48

  Fly   169 VDAAQGSGSGGGR--QRHAPLY--GRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNH-- 227
            :.|.||..|...:  ..:.|.|  |..:.|   ||....|:....|..|::......::...|
  Rat    49 LPATQGQASSSHQVANFNIPAYDQGLLLQA---PAVEHIVVTAADSSGSAATATFQSSQTLTHRS 110

  Fly   228 ---FREP--ASGPLRKL-------SVDLIKTYKHI---NEVYYAKKKRRAQQTQGDDDSSNKKER 277
               ..||  ..|..||.       ||.:|:.:..:   |.............|.....||.:.:.
  Rat   111 NVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDY 175

  Fly   278 KLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLN 342
            :|.       .|:.:.    ...:.||:...:|:|:||||.|.:....:..|||||:||...:..
  Rat   176 QLV-------QHEILC----SMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYAR 229

  Fly   343 QAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTR 407
            |.||||.:|..::..:|: :|..|:....|..:||.|||||:|..||||.|:...|..:.|...|
  Rat   230 QGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIR 293

  Fly   408 KFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSR 469
            ...||:.|||:.|.:  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||
  Rat   294 PILQQVATALMKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSR 356

  Fly   470 FYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHK 534
            :||:||::||:.:..|||||||||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||....|
  Rat   357 YYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTK 421

  Fly   535 TRKFFD----------KIVADGSYVLK---KNQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLD 584
            |.:||:          ::.....:.|:   |::..|||.   ...|.|:  :.:.|...|...|.
  Rat   422 TTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYI---FNCLDDMAQVNMSTDLEGTDMLA 483

  Fly   585 EPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRT----------------------- 626
            |.    :|..::.||:.:||..|...||||...|.|.|...|
  Rat   484 EK----ADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKR 544

  Fly   627 ----ADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATA 687
                .|..:.......|..|.:..:..:.:..:....|...: .||.:|...|||:|||.|.:.|
  Rat   545 RVHMYDTVSQIKSPFTTHVAPSTSTNLTMSFSNQLSTVHNQV-LSNQASVLASSSTAAAATLSLA 608

  Fly   688 -----------------AATAAGSSGSGSSVGGGSS----------------------------- 706
                             ||...|.:..|.|:..|::
  Rat   609 NSDVSLLNYQSALYPPSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTK 673

  Fly   707 -------------------AAQ------------------------------QQQAMPLPLPLPL 722
                               |||                              .|.|:|..|....
  Rat   674 HSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAA 738

  Fly   723 PLPPL---------AGPGGASD-------GQCHGLLMH------SVAANAMNNFSALSLQSNAH- 764
            ..|.|         |.|||...       .|..|:.:|      :|...||.:...|:...|||
  Rat   739 GRPALVEQTAAVLQAWPGGTQQILLPSAWQQLPGVALHNSVQPTAVIPEAMGSSQQLADWRNAHS 803

  Fly   765 ---------PPPSLANSHHSTNSLGSLN----HI----SPGSTGCHNNNSNSSNNNTRHSRLYGS 812
                     ..|||..:|.:..:...||    |:    ...|.....|..::..::|....:..|
  Rat   804 HGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSRKNKQSAPVSSTSSLEVLPS 868

  Fly   813 NMVNMVGHHNSGSSNNHNSISYPHAMECDP---PQMPPPPPNGHGRMRVPAIM----QLQPNSYA 870
            .:.::||.....:::::||: .|...:..|   |..|.||      :.|..|.    :.:.|.:.
  Rat   869 QVYSLVGSSPLRTTSSYNSL-VPVQDQHQPIIIPDTPSPP------VSVITIRSDTDEEEDNKFK 926

  Fly   871 PNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFLF 935
            |         ||||:    .|.:...|::.:.||                    |.:.|:.:..:
  Rat   927 P---------SSSSL----KARSNVISYVTVNDS--------------------PDSDSSLSSPY 958

  Fly   936 PSQPAGTLYG-----------TALGSLSDLPLPMPLPMSVPL-------QLPPSSSSSVSSGSAS 982
            |:.....|.|           ||...:....:.:| |:...|       |.....|||.:...||
  Rat   959 PTDTLSALRGNSGTLLEGPGRTAADGIGTRTIIVP-PLKTQLGDCTGATQASGLLSSSKTKPVAS 1022

  Fly   983 VG--SGGVGVGVVGQRRHITGPAA--QVGISQSVGSGSSGSATGASSSDASSSSP 1033
            |.  |.|..:...|.|....|.:|  .:.:||:..|.|      ||:|...||:|
  Rat  1023 VSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSS------ASTSQERSSNP 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	129/383 (34%)
		S_TKc	303..623	CDD:214567	126/337 (37%)
Hipk1	XP_038958716.1	STKc_HIPK1	174..528	CDD:271130	130/374 (35%)
		PHA03247	<623..930	CDD:223021	55/322 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348898
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740