Protein Alignment mnb and Hipk2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001416116.1
• Gene: Hipk2 / 362342
• RGDID: 1309349
• Length: 1196
• Species: Rattus norvegicus
• Alignment Length: 1102
• Identity: 259/1102 - (23%)
• Similarity: 410/1102 - (37%)
• Gaps: 302/1102 - (27%)

  Fly   145 SSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVD-----------AEDLP 198
            |..::|.|.:..:.|:.|||                   |:.:|.:..:           :..||
  Rat    27 SVKKLKVEPSSNWDMTGYGS-------------------HSKVYSQSKNIPPSQPASTTVSTSLP 72

  Fly   199 ATHRDVMHHHS--SPSSSSEVRAMQARIPNHFREPASGP---LRKLSVDLIKTYKHINEVYYAKK 258
            ..:..:.:..:  .|.|:..:....|...:...:...||   :|:.:|.|:.||:...      .
  Rat    73 IPNPSLPYEQTIIFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCG------L 131

  Fly   259 KRRAQQTQGDDD---------------------SSNKKERKLYNDGYDDDNHDYIIKNGE---KF 299
            ||::::.:....                     ::........|.|.:.:. ||.:...|   ..
  Rat   132 KRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEG-DYQLVQHEVLCSM 195

  Fly   300 LDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYY 364
            .:.||:...:|:|:||||||.:.......|||||:||...:..|.||||.:|..::...|:: |.
  Rat   196 TNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YN 259

  Fly   365 IVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIH 429
            .|:....|..:||.|||||:|..||||.|:...|..:.|...|...||:.|||:.|.:  |.:||
  Rat   260 FVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS--LGLIH 322

  Fly   430 CDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSL 491
            .|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::||:.:..|||||||
  Rat   323 ADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSL 387

  Fly   492 GCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVL------ 550
            ||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||....||.:||:: ..|..|.|
  Rat   388 GCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR-DTDSPYPLWRLKTP 451

  Fly   551 --------KKNQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLD 605
                    .|::..|||.   ...|.|:  :.:.|...|...|.|.    :|..:|.||:.:||.
  Rat   452 DDHEAETGIKSKEARKYI---FNCLDDMAQVNMTTDLEGSDMLVEK----ADRREFIDLLKKMLT 509

  Fly   606 FDPKTRVTPYYALQHNFF------------------------KR------TADEA-----TNTSG 635
            .|...|:||...|.|.|.                        ||      |.:::     |:.:.
  Rat   510 IDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAP 574

  Fly   636 AGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVS-SSSAAAPTAATAAATA-------- 691
            :.:|.......:..:.....:.......|..:|.....:: .|:...|:||:.||.|
  Rat   575 STSTNLTMTFNNQLTTVHNQAPTSTSATLSLANPEVSILNYQSTLYQPSAASMAAVAQRSMPLQT 639

  Fly   692 -----------------------AGSSGSGSSVGGGSSAAQQQQAMPL----PLPLPLPLPP--- 726
                                   .|...|.|...|.|  .:.:.|:|:    |...||.:.|
  Rat   640 GTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYS--VRMENAVPIVTQAPGAQPLQIQPGLL 702

  Fly   727 --LAGPGGASD-------GQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSL 782
              .|.||||..       .|..|:..|:            |:|..|..|.::|    .|..|.
  Rat   703 AQQAWPGGAQQILLPPAWQQLTGVATHT------------SVQHAAVIPETMA----GTQQLA-- 749

  Fly   783 NHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPP 847
                                :.|::..:||               ::|.|....|:......:|.
  Rat   750 --------------------DWRNTHAHGS---------------HYNPIMQQPALLTGHVTLPA 779

  Fly   848 PPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASH-------------- 898
            ..|...|   |..:|:.||.|...:........|:.:|:.....::.|.|.
  Rat   780 AQPLNVG---VAHVMRQQPTSTTSSRKSKQHQSSARNVSTCEVTSSQAISSPQRSKRVKENTPPR 841

  Fly   899 -LMMTDSSVISAS-AAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMP-L 960
             .|:..|...|.| ..|.|.|..:..::   ......:.|..|:.|:....:.|.:|...... .
  Rat   842 CAMVHSSPACSTSLTCGWGDGASSTTRD---RQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA 903

  Fly   961 PMS------------VPLQLPP--SSSSSVSSGSASVGSGGVGVGVV----GQRRHIT------- 1000
            |.|            |.:...|  .|||:.|..|....:|..|...:    |...|.|
  Rat   904 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGGLENHCTGNPRTII 968

  Fly  1001 ------------------GPAAQVG-ISQSVGSGSSGSATGASSSDASSSSPMVGVCVQQNP 1043
                              |||...| .|.|..|.||.:.|..|...:.|||..:.. .||.|
  Rat   969 VPPLKTQASEVLVECDSLGPAISTGHHSSSFKSKSSSTVTSTSGHSSGSSSGAIAY-RQQRP 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	136/390 (35%)
Hipk2	NP_001416116.1	None