Protein Alignment mnb and Dyrk2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 750
• Identity: 243/750 - (32%)
• Similarity: 349/750 - (46%)
• Gaps: 196/750 - (26%)

  Fly   139 VQGSSSSSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRD 203
            |..|:::||....||         |||..| :::.||||.|
  Fly   115 VSSSTTNSSNGGNER---------GSSTKS-NSSSGSGSSG------------------------ 145

  Fly   204 VMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGD 268
               :.:|.:.|.|::......|:...:.....|..|..:.:|.||   ||:|.          |.
  Fly   146 ---NSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYK---EVWYF----------GQ 194

  Fly   269 DDSSNKKE----RKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHV 329
            ..|.|..:    ....|.||||||.:|.|...:....||||..:|||||||||::|.||:...||
  Fly   195 HASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHV 259

  Fly   330 AIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLR 394
            |||||:|||.|||||.:|:.:|:.:...||:..:.::.:..:..:|.|||:.|||:|.|||:|::
  Fly   260 AIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIK 324

  Fly   395 NTNFRGVSLNLTRKFAQQL--CTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 457
            ..|:.|.|::|.|:|...:  |..||:    :.||||||||||||||.....|:||::||||||.
  Fly   325 KNNYNGFSMSLIRRFCNSIVKCLRLLY----KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCY 385

  Fly   458 LGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLG 522
            :.::||.||||||||||||:||:||..|||||||||||.|::||.|||.|.|||:|:..|:||||
  Fly   386 VDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450

  Fly   523 MPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPG 587
            :|||.|:..|.:.|.|||...|.....   |..||| :.|||:.|..||
  Fly   451 LPPKVLISVARRRRLFFDSRDAPRCIT---NTKGRK-RSPGSKSLAHIL---------------- 495

  Fly   588 HSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTA---------DEATNTSGAGATANAG 643
            |....|  |.|.:.|.|::||..|:||..|..|.|.:.:|         ..::::||..:.:...
  Fly   496 HCQDRY--FIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKS 558

  Fly   644 AGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAA 708
            :..|.|..:.|::|..|     ||.:|:.||.:::.|..|.:
  Fly   559 SCYSFSEISPGTNGPVV-----ASITSTTAVHNAAIATTTKS----------------------- 595

  Fly   709 QQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSH 773
             :||            ||         .|.||   |:              |||.|.|....::.
  Fly   596 -RQQ------------PP---------SQSHG---HA--------------QSNGHLPDIKLSAS 621

  Fly   774 HSTNSL---------------------------------GSLNHISPGSTGCHNNNSNSSNNNTR 805
            ...||:                                 ||.:|:|..:|..|...:.|......
  Fly   622 DKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAM 686

  Fly   806 HSRLYGSNMV----NMVGHHNSGSSNNHNSISYPH 836
            .|: |||:.:    :.|.|||:.::....:..:.|
  Fly   687 SSK-YGSSTLAHNHHNVTHHNASTATIATTTHHHH 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	161/349 (46%)
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	174/381 (46%)