Protein Alignment mnb and dyrk1ab

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001334760.1
• Gene: dyrk1ab / 327466
• ZFINID: ZDB-GENE-030131-5677
• Length: 719
• Species: Danio rerio
• Alignment Length: 883
• Identity: 422/883 - (47%)
• Similarity: 507/883 - (57%)
• Gaps: 204/883 - (23%)

  Fly   194 AEDLPATHRDVMHHHSSPSSSS-----------EVRAMQARIPNHFREPASGPLRKLSVDLIKTY 247
            |..:|.:|:.....|...:..|           .:.|.|..:|..||:|...||||||:||||||
Zfish     2 AAPMPHSHQQYSDCHQQSTDQSVTVLPYSDQTQALTASQRHMPQCFRDPTLAPLRKLSIDLIKTY 66

  Fly   248 KHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKG 312
            ||||||||||||||.||.|| :|||:|||||::||||||:|:||::|||||::||||||||||||
Zfish    67 KHINEVYYAKKKRRHQQGQG-EDSSHKKERKVFNDGYDDENYDYVVKNGEKWMDRYEIDSLIGKG 130

  Fly   313 SFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNH 377
            ||||||||||..||..||||||||||.|||||||||:|||:||:.|.|.|||||.||||||:|||
Zfish   131 SFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNH 195

  Fly   378 LCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNP 442
            ||||||:||||||||||||||||||||||||||||||||||||:||||:||||||||||||||||
Zfish   196 LCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNP 260

  Fly   443 KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSG 507
            |||||||||||||||||||||.|||||||||||||||:.||||||||||||||||||||||||||
Zfish   261 KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSG 325

  Fly   508 CNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILG 572
            .||||||||||||||:||.:::|.|.|.||||:|: :||::.:||.::|::||||.|||||.|||
Zfish   326 ANEVDQMNKIVEVLGIPPNHIMDLAPKARKFFEKL-SDGTWSIKKTKDGKRYKPPASRKLHAILG 389

  Fly   573 VETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAG 637
            ||.|||||||..|.||:|:||||||||||||||:|||||:.|||||||:|||:|.||.||||.:.
Zfish   390 VECGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTTDEGTNTSSSV 454

  Fly   638 ATA-------NAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSS--------SSAAAPTAATA 687
            :|:       ::|...|.||.:|||||          .|:||...|        ||....||..|
Zfish   455 STSPALEQSQSSGTTSSTSSSSGGSSG----------TSTSGRARSDPTHHHRHSSGHFGTAMPA 509

  Fly   688 AATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMN 752
                         :...:...|.:|    |...|:..|.:.||...:      :..|.|.
Zfish   510 -------------IDCDNLCPQARQ----PYHPPVVWPGIVGPEPVT------VETHPVQ----- 546

  Fly   753 NFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNM 817
                   ::..|.||....:.|.
Zfish   547 -------ETTFHVPPQHPKALHP------------------------------------------ 562

  Fly   818 VGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSS 882
              ||:....::|:                      ||:     ::..:|.....|        |.
Zfish   563 --HHHHHHHHHHH----------------------HGQ-----VIATRPRPRLYN--------SP 590

  Fly   883 SSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTA 947
            ::.|:...:......||.||..|..::|::......||.|..       |:.....||.||..:.
Zfish   591 TNSASTQDSMEVVHGHLSMTSLSSSASSSSTSSSSTGNHGNQ-------AYQLRHLPANTLDFSQ 648

  Fly   948 LGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGSGGVGVGVVGQRRHITG--------PAA 1004
            .||||         ||                        :|:|.....|..||        .|.
Zfish   649 NGSLS---------MS------------------------MGLGAFSNPRQETGMAGNPTYPVAT 680

  Fly  1005 QVGISQSVGSGSSGSATGASSSDASSSSPMVGVCVQQN 1042
            ..|....:..|..|...|....|    |||.||||||:
Zfish   681 NTGTGHFIAEGHLGMRQGIDRED----SPMTGVCVQQS 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	279/338 (83%)
dyrk1ab	NP_001334760.1	PKc_DYRK1	107..445	CDD:271128	279/338 (83%)