Protein Alignment mnb and clk4a

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_003199888.1
• Gene: clk4a / 321857
• ZFINID: ZDB-GENE-030131-576
• Length: 496
• Species: Danio rerio
• Alignment Length: 601
• Identity: 158/601 - (26%)
• Similarity: 244/601 - (40%)
• Gaps: 183/601 - (30%)

  Fly    55 NGHHNHHHPPHYINYLAQIGCQHRVRNWPTNGNQDQADDDDAGHQIISKFLPKSAWDTVLLDVKR 119
            |.:..|||  ||.|     ...|.:....:|...|.::              |.|       |.|
Zfish    39 NKYRKHHH--HYKN-----SDGHCLEKRSSNERLDTSE--------------KHA-------VFR 75

  Fly   120 DVDEDG-------DRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGGSVDAAQGSGS 177
            |.:.:|       :|:|||               ||
Zfish    76 DHEHNGYAACKDKERNRDR---------------SR----------------------------- 96

  Fly   178 GGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVD 242
              .|:||.             ...||...||.|.||.:.:|:.:.|
Zfish    97 --SRERHR-------------ERERDRDWHHYSKSSGNSMRSSRHR------------------- 127

  Fly   243 LIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDS 307
                ::|         :.|......|..|..:|..:...|  |::.| .:..:|:....||||..
Zfish   128 ----HRH---------RHRRSHPHSDSRSHRRKRSRSVED--DEEGH-LVYHSGDMLRARYEIVC 176

  Fly   308 LIGKGSFGQVVKAYDHEE-QCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRH 371
            .:|:|:||:||:..|||: ...:|:|||||.:.:.:.|..||::||.:|..|.:.:|..|::...
Zfish   177 TLGEGAFGKVVECIDHEKVGARIALKIIKNIERYRDAALSEVEVLEQINSLDCDRRYACVRMYDW 241

  Fly   372 FMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPEN 436
            |....|:|:.||||..:.||.|:..||:...:|..|..|.|:..|:.||...:|.  |.||||||
Zfish   242 FDHHGHICIAFELLGLSTYDFLKENNFQPFYINHIRHMAYQIIRAVRFLHKNKLT--HTDLKPEN 304

  Fly   437 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDL 484
            ||..|.                 |...:|:||||::....:.....:.:|.||:|||:|.:.:..
Zfish   305 ILFVNSEYNIRYNSKMKRDERTVKNPDVKVVDFGNATYEHEHHTSVVSTRHYRAPEVILDLGWSH 369

  Fly   485 AIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF--DKIVAD-- 545
            :.|:||:||||:|.:.|..||...:..:.:..:..|||..|.::|.:..|:| |.  ||:..|
Zfish   370 SCDVWSVGCILIEYYLGSTLFQTHDSKEHLAMMERVLGPIPTHMLQKTRKSR-FVRNDKLDWDIH 433

  Fly   546 ---GSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFD 607
               |.||.|:.:..|:|....|                          ||:.:..|||.|||::|
Zfish   434 SSSGRYVRKQCKPLRQYLVSSS--------------------------SDHEQLFDLIERMLEYD 472

  Fly   608 PKTRVTPYYALQHNFF 623
            ...|:|...|::|.||
Zfish   473 VTKRITLDEAIKHPFF 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	117/360 (33%)
clk4a	XP_003199888.1	Protein Kinases, catalytic domain	159..488	CDD:473864	115/358 (32%)