Protein Alignment mnb and Dyrk4

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_038964750.1
• Gene: Dyrk4 / 312721
• RGDID: 1306800
• Length: 649
• Species: Rattus norvegicus
• Alignment Length: 661
• Identity: 195/661 - (29%)
• Similarity: 312/661 - (47%)
• Gaps: 141/661 - (21%)

  Fly   136 VLMVQGSSSSSSRMKAERALYYTMSAYGSSGGSVDA-----------------AQGSGSGGGRQR 183
            ::.:|..||.:.::::.|......|...|:...||.                 .:||......|.
  Rat    60 LVQLQKPSSKTKKLRSNRCSQKNPSTSSSAFPFVDTKGKKNTVNFPHIGNKTLPKGSTLYQENQI 124

  Fly   184 HAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVR--AMQARIPNHFREPASGPLRKLSVDLIKT 246
            |..|....:...::|.:       .|:.:..::|:  .:...:|...:.|.:      :.:.:|.
  Rat   125 HNQLLSSELKTSEIPFS-------FSTKAQDTKVQDTKLHPELPKRHKVPLT------AAEALKF 176

  Fly   247 YKH------------INEVYY----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKN 295
            :|:            .:|:::    |||             .|....|.....:||::..|:...
  Rat   177 FKNQLSPYEQSEILGYSELWFLGLDAKK-------------LNVVPEKFSKTSFDDEHGSYVKVL 228

  Fly   296 GEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAE 360
            .:....|||:..:|||||||||.|..||:....||:|||:|||.|.:||.:|:|:||.:.|.|.:
  Rat   229 HDHIAYRYEVLDMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKD 293

  Fly   361 NKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQL--CTALLFLSTP 423
            |.:.:|.:|..|.:|||||:.||||..|||:|::|.:|:|.||::.|:|...:  |..:|::.
  Rat   294 NTHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFQGFSLSIVRRFTLSVLKCLQMLYVE-- 356

  Fly   424 ELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDM 488
              .|||||||||||:|.:..:..:|::||||||...|::|.||||||||||||:||..|::||||
  Rat   357 --KIIHCDLKPENIVLYHRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDM 419

  Fly   489 WSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKN 553
            ||||||:.|::||.|||.|.|||:|:..|:||||:||.:|:..|.:.:.|||      |..|.||
  Rat   420 WSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPTHLIQTATRRQIFFD------SKGLPKN 478

  Fly   554 --QNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDY-LKFKDLILRMLDFDPKTRVTPY 615
              .|..:.:.|.|:.|..:                   |..| ..|.|.:.|.|.::|..|:||.
  Rat   479 ITNNRGEKRYPNSKDLPMV-------------------VKTYDSSFLDFLRRCLVWEPSLRMTPD 524

  Fly   616 YALQHNFF----------------KRTADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGL 664
            .||:|.:.                |.....::.||......:..:.|:...
  Rat   525 QALKHAWIHEPRKFKPWPRPQIQRKPGVSSSSETSKDKTEEHQASKGTKDE-------------- 575

  Fly   665 GASNSSSGAVSSSSAAAPTAATAAATA-------------AGSSGSGSSVGGGSSAAQQQQAMPL 716
             |:..::..:.......|.::....::             |.:||...:| .||..:::||....
  Rat   576 -ATKETTDKLKDEPEKHPESSCKRQSSIQHLANTVQLPNLAEASGKPEAV-AGSETSEEQQCTSS 638

  Fly   717 PLPLPLPLPPL 727
            |....: |||:
  Rat   639 PKSTNI-LPPI 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	150/359 (42%)
		S_TKc	303..623	CDD:214567	147/324 (45%)
Dyrk4	XP_038964750.1	PKc_DYRK4	192..532	CDD:271127	157/381 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920