Protein Alignment mnb and Dyrk1b

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001402788.1
• Gene: Dyrk1b / 308468
• RGDID: 1307223
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 674
• Identity: 371/674 - (55%)
• Similarity: 443/674 - (65%)
• Gaps: 105/674 - (15%)

  Fly   163 GSSGGSVDAAQGSGSGGGRQRHAPL------------------YGRFVDAEDLPATHRDVMHHHS 209
            |.|||   .::|:|........||.                  :|.|..... |..|..|:
  Rat    27 GLSGG---GSRGAGCEKAPPGRAPAPGLTPLRPSEPTMAVPPGHGPFSGFPG-PQEHTQVL---- 83

  Fly   210 SPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNK 274
                 .:||.:..|:|..||:..|.||||||||||||||||||||||||||||||.. ..|||.|
  Rat    84 -----PDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAP-PQDSSTK 142

  Fly   275 KERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKP 339
            ||:|:.|.||||||||||:::||::|:||||||||||||||||||||||:.|..||||||||||.
  Rat   143 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKA 207

  Fly   340 FLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLN 404
            ||||||||::|||:||:.|.|.|||||.||||||:||||||||||||||||||||||:|||||||
  Rat   208 FLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLN 272

  Fly   405 LTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSR 469
            ||||.|||||||||||:||||:|||||||||||||||||||||||||||||||||||||.|||||
  Rat   273 LTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSR 337

  Fly   470 FYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHK 534
            ||||||||||..||||||||||||||||||||||||||.||||||::||||||:||..:|:||.|
  Rat   338 FYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPK 402

  Fly   535 TRKFFDKIVADGSYVLKKNQNGRK-YKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKD 598
            .||:|::: ..|.:.|::.:..|| |:.||:|:|.::|||:||||||||..|||||.:|||:|:|
  Rat   403 ARKYFERL-PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD 466

  Fly   599 LILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATAN----------AGAGGSGSSGAG 653
            |:||||:::|..|::|..||||.||:|||||||||..||::|:          :.:..|..|.:|
  Rat   467 LVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSG 531

  Fly   654 GSSG---------------GGVGGGLGASNSSSGAVSSSSAAAPTAA------TAAATAAGSSGS 697
            ||||               ||.|..:.....:|..|..|....|.|.      |..|..:||
  Rat   532 GSSGSSSDNRAYRYSNRYCGGPGPPITDCEMNSPQVLPSQPLRPWAGGDVPHKTHQAPTSGS--- 593

  Fly   698 GSSVGGGSSAAQQQQAMPLPLPLPLPLPP-------LAGPGGASDGQCHGLLMHSVAANAMNNFS 755
             :.:|.|:....|.:.:..| |.|...||       |.|    |...|
  Rat   594 -TLLGTGAQLPPQPRCLGRP-PSPTSPPPPELMDVSLVG----SPPDC----------------- 635

  Fly   756 ALSLQSNAHPPPSLANSHHSTNSL 779
                 |..||.|  |..|.:.::|
  Rat   636 -----SPPHPAP--APQHPAASAL 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	259/339 (76%)
Dyrk1b	NP_001402788.1	PHA03378	<3..147	CDD:223065	56/133 (42%)
		PKc_DYRK1	157..496	CDD:271128	259/339 (76%)