Protein Alignment mnb and Hipk4

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001019947.1
• Gene: Hipk4 / 308449
• RGDID: 1307541
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 174/619 - (28%)
• Similarity: 247/619 - (39%)
• Gaps: 149/619 - (24%)

  Fly   301 DRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYI 365
            |.|:|..::|||:||:|.|.:.......|||||:||........:.|:|||..:...|.: :.::
  Rat     9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPD-EAHV 72

  Fly   366 VKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHC 430
            ::....|.......||||||..||::..:..||..:.....|....|:..||..|.  ||.|||.
  Rat    73 IRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLK--ELAIIHA 135

  Fly   431 DLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIY---HYIQSRFYRSPEVLLGIQYDLAIDMWS 490
            |||||||:|.:..|.  .:|::||||:....:..|   .||||||||:||:|||:.:...:|:||
  Rat   136 DLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWS 200

  Fly   491 LGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIV---ADGSYVLKK 552
            |||::.|:|.|.||:.|.||.||:..|.|..|:|..:||..|.|...||.:..   |...:.||.
  Rat   201 LGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKS 265

  Fly   553 NQN---GRKYKPPGSRK--LHDILGVET--GGPGGRRLDEPGHSV----SDYLKFKDLILRMLDF 606
            :.:   ..|.:|...||  |..:..:||  ||....||..|....    :|.....:||.|||.:
  Rat   266 SADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVNRLSFPDREALAEHADLKSMVELIKRMLTW 330

  Fly   607 DPKTRVTPYYALQHNFFK----RTADEAT---NTSGAG--------------ATANAGAG----- 645
            :...|::|..||:|.|..    |:|.|||   ..|..|              ..|||..|
  Rat   331 ESHERISPSAALRHPFVSMQQLRSAHEATRYYQLSLRGCRLSLQVDGKPPPPVIANAEDGPPYYR 395

  Fly   646 ---GSGSSGAGGSSGGG-------------------------VGGGLGASNSSSGAVSSSSAAAP 682
               ...::|.||.:|.|                         ...||. |::.:..||...|...
  Rat   396 LAEEEETAGLGGVTGSGSFFREDKAPGMQRAIDQLDDLSLQEARRGLW-SDTRADMVSDMLAPLK 459

  Fly   683 TAAT-------------------------AAATAAGSS-----------------------GSGS 699
            .|.|                         |....|||.                       |||.
  Rat   460 VATTSHRVPDSGPEPILAFYGSRLTGRHKARKAPAGSKSDSNFSNLIRLSQASPEDAGSCRGSGW 524

  Fly   700 SVGGGSSAAQQQQAMP-----------LPLPLPLPLPPLAGPGGASDGQCHGLLMHSV--AANAM 751
            ..|.|.:.:.:..|:|           .|:......|.|..|.|     |.|..::..  ....:
  Rat   525 EEGEGHTTSTEPSAIPQREGDGPSIKDRPMDAERSGPELFDPSG-----CPGEWLNEPEWTLEGI 584

  Fly   752 NNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHI 785
            ....|..|.:. ||.|     |....:...|.|:
  Rat   585 RGSRAQGLPAR-HPHP-----HGPPRTTSFLQHV 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	125/349 (36%)
Hipk4	NP_001019947.1	Protein Kinases, catalytic domain	11..347	CDD:473864	122/338 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..616		26/137 (19%)