DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mnb and Dyrk3

DIOPT Version :9

Sequence 1:NP_728107.2 Gene:mnb / 32771 FlyBaseID:FBgn0259168 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_001019938.1 Gene:Dyrk3 / 304775 RGDID:1310924 Length:586 Species:Rattus norvegicus


Alignment Length:512 Identity:183/512 - (35%)
Similarity:268/512 - (52%) Gaps:84/512 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 SSPS----SSSEVRAMQARIPNHFREPASGPLRKLSV---DLIKTYKH------------INEVY 254
            |||:    ||..:..::..:       :|.|.:.|.:   ..:|.|||            ..|:|
  Rat   111 SSPASQGKSSDSLGTVKCSL-------SSRPSKVLPLTPEQALKQYKHHLTAYEKLEIISYPEIY 168

  Fly   255 Y----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFG 315
            :    |||:      ||.....|       |.||||.:..||....:....|||:..:|||||||
  Rat   169 FVGPNAKKR------QGVIGGPN-------NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFG 220

  Fly   316 QVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCL 380
            ||.:.|||:.:.:||:|:::|:|.|..||..|:::||.:.:.|......::.:...|.:|||:|:
  Rat   221 QVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCM 285

  Fly   381 VFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS 445
            .|||||.:||:|::...|:|.|:.|.|||||.:..:|..|.  :..|||||||||||||.:..||
  Rat   286 AFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH--KNKIIHCDLKPENILLKHHGRS 348

  Fly   446 AIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNE 510
            |.|::||||||...|::|.||||||||:||::||.:|...||:||.||||.|:.||:|||.|.:|
  Rat   349 ATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDE 413

  Fly   511 VDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK----------IVADGSYVL--KKNQNGRKYKPPG 563
            .||:..::|:|||||:.||:|:.:.:.|.:.          ...||..||  .:::.|:|..|||
  Rat   414 GDQLACMMELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVTTQTDGRVVLLGGRSRRGKKRGPPG 478

  Fly   564 SRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTAD 628
            |:.....|                ....||| |.:.:.|.|.:||..|:||..||:|.:..::|.
  Rat   479 SKDWAAAL----------------KGCDDYL-FIEFLKRCLQWDPSARLTPAQALRHPWISKSAP 526

  Fly   629 EATNT---SGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAP 682
            ....|   ||........|    ..|.|......||   .||...:..:|.:|.:.|
  Rat   527 RPLTTDKVSGKRVVNPTNA----FQGLGSKLPPVVG---IASKLKANLMSETSGSIP 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mnbNP_728107.2 PKc_DYRK1 289..628 CDD:271128 144/350 (41%)
S_TKc 303..623 CDD:214567 141/331 (43%)
Dyrk3NP_001019938.1 Disordered. /evidence=ECO:0000250|UniProtKB:O43781 1..187 20/95 (21%)
PKc_DYRK2_3 142..521 CDD:271126 161/410 (39%)
S_TKc 208..521 CDD:214567 141/331 (43%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43781 467..480 5/12 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166348893
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162948at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.850

Return to query results.
Submit another query.