DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and Clk1

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001100383.2	Gene:	Clk1 / 301434	RGDID:	1311469	Length:	483	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	151/521 - (28%)
Similarity:	232/521 - (44%)	Gaps:	107/521 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SSSSSSRMKAER--ALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLY--GRFVDAEDLPATHR 202
            ||||..|.|...  |..|....|..|     ....|.....|..|...|  .|:||     ....
  Rat    24 SSSSHKRRKRSHSSARDYKRCKYNHS-----KTTDSYYLESRSIHEKAYHSRRYVD-----EYRN 78

  Fly   203 DVM-----HHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRA 262
            |.|     :.:..|.|         |..|| ...:||...:.|      ||..:..::....||
  Rat    79 DYMTYEPGYPYGEPGS---------RYQNH-SSKSSGRSGRSS------YKSKHRSHHHTSHRR- 126

  Fly   263 QQTQGDDDSSNKKERKLYNDGYDDDNHDYII-KNGEKFLDRYEIDSLIGKGSFGQVVKAYDHE-E 325
                    |..|..|:..:...:||...::| ::|:....||||...:|:|:||:||:..||: .
  Rat   127 --------SHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVG 183

  Fly   326 QCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLY 390
            ..|||:||:||...:...||.|:::||.:|..|..:.:..|::...|..|.|:|:|||||..:.|
  Rat   184 GRHVAVKIVKNVDRYCEAAQSEIQVLEHLNATDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTY 248

  Fly   391 DLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLC--------NPKRSA- 446
            |.::..:|....::..||.|.|:|.::.||.:.:|.  |.||||||||..        |||...
  Rat   249 DFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLT--HTDLKPENILFVKSDYTEAYNPKMKRD 311

  Fly   447 --------IKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEP 503
                    ||:|||||:....:.....:.:|.||:|||:|.:.:....|:||:||||:|.:.|..
  Rat   312 ERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFT 376

  Fly   504 LFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKF------FDKIVADGSYVLKKNQNGRKYKPP 562
            :|...:..:.:..:..:||..||:::::..|...|      :|:..:.|.||      .|:.||.
  Rat   377 VFPTHDSREHLAMMERILGPLPKHMIEKTRKRTYFHHDRLDWDEHSSAGRYV------SRRCKPL 435

  Fly   563 GSRKL-----HDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNF 622
            ....|     |::|                         .|||.:||::||..|:|...||:|.|
  Rat   436 KEFMLSQDAEHELL-------------------------FDLIGKMLEYDPAKRITLKEALKHPF 475

  Fly   623 F 623
            |
  Rat   476 F 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	115/365 (32%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	110/348 (32%)
Clk1	NP_001100383.2	PKc_CLK1_4	147..476	CDD:271115	113/361 (31%)
Clk1	NP_001100383.2	S_TKc	160..476	CDD:214567	110/348 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740