Protein Alignment mnb and HIPK2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Alignment Length: 1106
• Identity: 250/1106 - (22%)
• Similarity: 400/1106 - (36%)
• Gaps: 328/1106 - (29%)

  Fly   145 SSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVD-----------AEDLP 198
            |..::|.|.:..:.|:.|||                   |:.:|.:..:           :..||
Human   206 SVKKLKIEPSSNWDMTGYGS-------------------HSKVYSQSKNIPLSQPATTTVSTSLP 251

  Fly   199 ATHRDVMHHHS--SPSSSSEVRAMQARIPNHFREPASGP---LRKLSVDLIKTYKHINEVYYAKK 258
            ..:..:.:..:  .|.|:..:....|...:...:...||   :|:.:|.|:.||:...      .
Human   252 VPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCG------L 310

  Fly   259 KRRAQQTQGDDD---------------------SSNKKERKLYNDGYDDDNHDYIIKNGE---KF 299
            ||::::.:....                     ::........|.|.:.:. ||.:...|   ..
Human   311 KRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEG-DYQLVQHEVLCSM 374

  Fly   300 LDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYY 364
            .:.||:...:|:|:||||||.:.......|||||:||...:..|.||||.:|..::...|:: |.
Human   375 TNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YN 438

  Fly   365 IVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIH 429
            .|:....|..:||.|||||:|..||||.|:...|..:.|...|...||:.|||:.|.:  |.:||
Human   439 FVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS--LGLIH 501

  Fly   430 CDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSL 491
            .|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::||:.:..|||||||
Human   502 ADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSL 566

  Fly   492 GCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVL------ 550
            ||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||....||.:||:: ..|..|.|
Human   567 GCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR-DTDSPYPLWRLKTP 630

  Fly   551 --------KKNQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLD 605
                    .|::..|||.   ...|.|:  :.:.|...|...|.|.    :|..:|.||:.:||.
Human   631 DDHEAETGIKSKEARKYI---FNCLDDMAQVNMTTDLEGSDMLVEK----ADRREFIDLLKKMLT 688

  Fly   606 FDPKTRVTPYYALQHNFF------------------------KR--------------------- 625
            .|...|:||...|.|.|.                        ||
Human   689 IDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAP 753

  Fly   626 -TADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVS-SSSAAAPTAATAA 688
             |:...|.|.....|.......|.:|..           :..:|.....:: .|:...|:||:.|
Human   754 STSTNLTMTFNNQLTTVHNQAPSSTSAT-----------ISLANPEVSILNYPSTLYQPSAASMA 807

  Fly   689 ATA-------------------------------AGSSGSGSSVGGGSSAAQQQQAMPL----PL 718
            |.|                               .|...|.|...|.|  .:.:.|:|:    |.
Human   808 AVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYS--VRMENAVPIVTQAPG 870

  Fly   719 PLPLPLPP-----LAGPGGASD-------GQCHGLLMH------SVAANAMNNFSALSLQSNAH- 764
            ..||.:.|     .|.|.|...       .|..|:..|      :|....|.....|:...|.|
Human   871 AQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA 935

  Fly   765 ---------PPPSLANSHHSTNSLGSLN----HISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVN 816
                     ..|:|...|.:..:...||    |:.        ....:|..::|.|:.:.|::.|
Human   936 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVM--------RQQPTSTTSSRKSKQHQSSVRN 992

  Fly   817 MVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHG----------------------RMRVP 859
            :    ::...::..:||.|...:......||.....|.                      |.|..
Human   993 V----STCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQT 1053

  Fly   860 AIMQLQPN------------------SYAPNSV-----------------PYYGNMSSSSVAAAA 889
            .::...|:                  .:||.|.                 ||..:.|::|..:..
Human  1054 IVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQ 1118

  Fly   890 AAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDL 954
            ..|....::...|..|:                :|..|.:....:.|  |..|.....|.....|
Human  1119 QRAGHNNANAFDTKGSL----------------ENHCTGNPRTIIVP--PLKTQASEVLVECDSL 1165

  Fly   955 PLPMPLPMSVPLQLPPSSSSSVSSGSASV-----GSGGVGVGVVGQRRHITGPAAQ----VGISQ 1010
                     ||:.....|||..|..|::|     .|.|...|.:..|:...||..|    :.:||
Human  1166 ---------VPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQ 1221

  Fly  1011 S 1011
            :
Human  1222 A 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	136/406 (33%)
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	133/364 (37%)