DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnb and Clk4

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_038941309.1	Gene:	Clk4 / 287269	RGDID:	1310274	Length:	507	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	142/527 - (26%)
Similarity:	231/527 - (43%)	Gaps:	114/527 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAE----------------DLPATHRDVMHHHSSPS 212
            |..||....:.|.|.....||...:.:|.|.:                |....|..|..|:
  Rat    22 SYSGSHKRKRRSHSSTQENRHCKPHHQFKDTDWDLCVQIFACGYFLRVDSKKRHFQVKGHY---- 82

  Fly   213 SSSEVRAMQAR-------------------IPNHFREPASGPLRKLSVDLIKTYK-HINEVYYAK 257
              .|.|.:..|                   :|.|:..           |:..||: |.::.....
  Rat    83 --LEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHR-----------DIESTYRIHCSKSSVRS 134

  Fly   258 K----KRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYII-KNGEKFLDRYEIDSLIGKGSFGQV 317
            :    ||:..:......|.:|..|:..:...:||...::| ::|:....||||...:|:|:||:|
  Rat   135 RRSSPKRKRNRHCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 199

  Fly   318 VKAYDH-EEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLV 381
            |:..|| .:..|||:||:||...:...|:.|:::||.:|..|..:.:..|::...|....|:|:|
  Rat   200 VECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIV 264

  Fly   382 FELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNP---- 442
            ||||..:.||.::..:|....::..|:.|.|:|.::.||...:|.  |.||||||||....
  Rat   265 FELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPENILFVKSDYVV 327

  Fly   443 -------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCI 494
                         |.:.||:|||||:....:.....:.:|.||:|||:|.:.:....|:||:|||
  Rat   328 KYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCI 392

  Fly   495 LVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF-------DKIVADGSYVLKK 552
            |:|.:.|..:|...:..:.:..:..:||..|.:::.:..| ||:|       |:..:.|.||
  Rat   393 LIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRK-RKYFHHNQLDWDEHSSAGRYV--- 453

  Fly   553 NQNGRKYKPPGSRKL-HDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYY 616
               .|:.||.....| ||                     .::.|..||:.|||::||..|:|...
  Rat   454 ---RRRCKPLKEFMLCHD---------------------EEHEKLFDLVRRMLEYDPTKRITLDE 494

  Fly   617 ALQHNFF 623
            ||||.||
  Rat   495 ALQHPFF 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	113/362 (31%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	108/345 (31%)
Clk4	XP_038941309.1	PKc_CLK1_4	172..501	CDD:271115	111/358 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740