DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and ppk15

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_593830.1	Gene:	ppk15 / 2542228	PomBaseID:	SPAC823.03	Length:	534	Species:	Schizosaccharomyces pombe

Alignment Length:	471	Identity:	178/471 - (37%)
Similarity:	253/471 - (53%)	Gaps:	74/471 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 RHAPLYGRFVDAEDLPAT----HRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDL 243
            ||....|..:.|...|||    :|.|..|.|..|                      ||..::|.|
pombe    30 RHVSSSGTTLFAPVKPATKKYNYRRVSPHGSYIS----------------------PLEAMTVKL 72

  Fly   244 IKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYII--------KNGEKFL 300
            ..||...|..:....::..::      ...|....::|.|:|:.||||::        ..|.|:|
pombe    73 ADTYSICNPKFQFSSEQNPRR------PLTKPSEGVHNHGFDNVNHDYVLYVNDLLGTDEGRKYL 131

  Fly   301 DRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMM-NRADAENKYY 364
                |...:|.|:||||.:..|.:.|..||||:||||..|.||..:||.:||:: |:.|.|:|.:
pombe   132 ----ILDTLGHGTFGQVARCQDLKTQQIVAIKVIKNKPAFYNQCVMEVSILELLNNKYDPEDKRH 192

  Fly   365 IVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQL--CTALLFLSTPELNI 427
            :::|...||.:|||||||||||.|||:|::...|||:.|:|.|.||.||  ||:||    .:..|
pombe   193 LIRLYDQFMHKNHLCLVFELLSINLYELIKQNQFRGLHLSLVRSFATQLLSCTSLL----KQARI 253

  Fly   428 IHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLG 492
            ||||||||||||.:.....:|::||||:|...|.:|.||||||||||||:||:.|:..|||||||
pombe   254 IHCDLKPENILLQDLSSPIVKVIDFGSACHERQTVYTYIQSRFYRSPEVILGLHYNCGIDMWSLG 318

  Fly   493 CILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADG--SYVLKK--- 552
            |||.|:..|.|||.|.:|.:|:.:||::||.||.::|:....::|:::....:|  :|.||.
pombe   319 CILAELFLGLPLFPGNSEYNQLCRIVDMLGNPPTWMLEMGKNSKKYYNSGFVNGRKTYELKSIEQ 383

  Fly   553 --------NQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDY---LKFKDLILRMLDF 606
                    .|.|::|.  |.:.|..|:   ...|  ||...|..:..::   |.|.|.|.:.|:.
pombe   384 FSIENNKTEQPGKQYF--GEKTLDAIV---LNYP--RRKTTPKLTPEEHEERLCFIDFIKQFLEL 441

  Fly   607 DPKTRVTPYYALQHNF 622
            :|..|.||..|..|.|
pombe   442 NPLKRWTPDQAKNHPF 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	154/361 (43%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	148/339 (44%)
ppk15	NP_593830.1	PKc_YAK1	130..458	CDD:271114	149/343 (43%)
ppk15	NP_593830.1	S_TKc	130..458	CDD:214567	149/343 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X1406
TreeFam	1	0.960	-	-
	5	4.800