Protein Alignment mnb and Dyrk1a

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_036923.1
• Gene: Dyrk1a / 25255
• RGDID: 2528
• Length: 763
• Species: Rattus norvegicus
• Alignment Length: 920
• Identity: 442/920 - (48%)
• Similarity: 533/920 - (57%)
• Gaps: 202/920 - (21%)

  Fly   165 SGGSVDAAQGSGSGGGRQRHAPLYGRFVD----AEDLPATHR-------DVMHHHSSPSSSS--- 215
            :||...|.:.|.     .|.||.:.....    |..:|.:|:       ::.....|..|.|
  Rat     3 TGGETSACKPSS-----VRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPNISDQQVSALSYSDQI 62

  Fly   216 ----------EVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDD 270
                      ::..:|.|:|..||:||:.|||||||||||||||||||||||||||.||.|| ||
  Rat    63 QQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQG-DD 126

  Fly   271 SSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIK 335
            ||:|||||:|||||||||:|||:|||||::||||||||||||||||||||||..||..|||||||
  Rat   127 SSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK 191

  Fly   336 NKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRG 400
            |||.|||||||||:|||:||:.|.|.|||||.||||||:|||||||||:||||||||||||||||
  Rat   192 NKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRG 256

  Fly   401 VSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHY 465
            ||||||||||||:|||||||:||||:|||||||||||||||||||||||||||||||||||||.|
  Rat   257 VSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY 321

  Fly   466 IQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLD 530
            ||||||||||||||:.||||||||||||||||||||||||||.||||||||||||||:||.::||
  Rat   322 IQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILD 386

  Fly   531 QAHKTRKFFDKIVADGSYVLKKNQNG-RKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYL 594
            ||.|.||||:|: .||::.|||.::| |:|||||:||||:|||||||||||||..|.||:|:|||
  Rat   387 QAPKARKFFEKL-PDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL 450

  Fly   595 KFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSSGA 652
            |||||||||||:|||||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||.:
  Rat   451 KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515

  Fly   653 GGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLP 717
            |||||          .|:||...|.    ||.....:            ||..:||.|
  Rat   516 GGSSG----------TSNSGRARSD----PTHQHRHS------------GGHFAAAVQ------- 547

  Fly   718 LPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSL 782
                           |.|.:.|       :......|.|....|....|..:....|....  :.
  Rat   548 ---------------AMDCETH-------SPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE--TT 588

  Fly   783 NHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPP 847
            .|::|.....|:::.|||:::..|             ||     ::|:
  Rat   589 FHVAPQQNALHHHHGNSSHHHHHH-------------HH-----HHHH----------------- 618

  Fly   848 PPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAA 912
                 ||:       |...|...|.   .|.:.::||  :...:.....||..||..|..:.|::
  Rat   619 -----HGQ-------QALGNRTRPR---VYNSPTNSS--STQDSMEVGHSHHSMTSLSSSTTSSS 666

  Fly   913 GGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVS 977
            ......||.|..         .:.::|                                    |:
  Rat   667 TSSSSTGNQGNQ---------AYQNRP------------------------------------VA 686

  Fly   978 SGSASVGSGG---VGVGVVGQRRHITGPAAQVGISQSVGSG-----SSGSATGASSSDASSSSPM 1034
            :.:...|..|   |.:.|....|..||.|.......|..:|     :.|..|....:| ...|||
  Rat   687 ANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGAD-REESPM 750

  Fly  1035 VGVCVQQNPV 1044
            .||||||:||
  Rat   751 TGVCVQQSPV 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	284/339 (84%)
Dyrk1a	NP_036923.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..56		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		17/21 (81%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		13/17 (76%)
		PKc_DYRK1	148..484	CDD:271128	282/336 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		24/33 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		21/80 (26%)
		Histidine-rich domain (HRD). /evidence=ECO:0000250|UniProtKB:Q13627	595..625		11/76 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..679		25/143 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763		12/18 (67%)