Protein Alignment mnb and Hipk4

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001028487.2
• Gene: Hipk4 / 233020
• MGIID: 2685008
• Length: 616
• Species: Mus musculus
• Alignment Length: 729
• Identity: 189/729 - (25%)
• Similarity: 269/729 - (36%)
• Gaps: 185/729 - (25%)

  Fly   301 DRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYI 365
            |.|:|..::|||:||:|.|.:.......|||||:||........:.|:|||..:...|.: :.::
Mouse     9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPD-EAHV 72

  Fly   366 VKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHC 430
            ::....|.......||||||..||::..:..||..:.....|....|:..||..|.  ||.|||.
Mouse    73 IRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLK--ELAIIHA 135

  Fly   431 DLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIY---HYIQSRFYRSPEVLLGIQYDLAIDMWS 490
            |||||||:|.:..|.  .:|::||||:....:..|   .||||||||:||:|||:.:...:|:||
Mouse   136 DLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWS 200

  Fly   491 LGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIV---ADGSYVLKK 552
            |||::.|:|.|.||:.|.||.||:..|.|..|:|..:||..|.|...||.:..   |...:.||.
Mouse   201 LGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKS 265

  Fly   553 NQN---GRKYKPPGSRK--LHDILGVET--GGPGGRRLDEPGHSV----SDYLKFKDLILRMLDF 606
            :.:   ..|.:|...||  |..:..:||  ||....||..|....    :|.....:||.|||.:
Mouse   266 SADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSRLSFPDREALAEHADLKSMVELIKRMLTW 330

  Fly   607 DPKTRVTPYYALQHNFFK----RTADEAT---NTSGAGATANAGAGGSGSSGAGGSSGGGVGGGL 664
            :...|::|..||:|.|..    |:|.|||   ..|..|...:....|
Mouse   331 ESHERISPSAALRHPFVSMQQLRSAHEATRYYQLSLRGCRLSLQVDG------------------ 377

  Fly   665 GASNSSSGAVSSSSAAAP---------TAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPL 720
               ......::|:....|         ||.....|.:||........|...|..|...:.|
Mouse   378 ---KPPPPVIASAEDGPPYYRLAEEEETAGLGGVTGSGSFFREDKAPGMQRAIDQLDDLSL---- 435

  Fly   721 PLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAH------PPPSLANSHHSTNSL 779
                          .....||...:.|....:....|.:.|.:|      |.|.||
Mouse   436 --------------QEARRGLWSDTRADMVSDMLVPLKVASTSHRVPDSGPEPILA--------- 477

  Fly   780 GSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHN-----SGSSNNHNSISYPHAME 839
                                         .|||   .:.|.|.     :||.::.|..:.....:
Mouse   478 -----------------------------FYGS---RLTGRHKARKAPAGSKSDSNFSNLIRLSQ 510

  Fly   840 CDPPQMPPPPPNG--HGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMT 902
            ..|....|...:|  .|..|..:                                         |
Mouse   511 ASPEDAGPCRGSGWEEGEGRTTS-----------------------------------------T 534

  Fly   903 DSSVISASAAGGGQG-------GGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPL 960
            :.||| ....|.|.|       ...||.....||:....:.|:|..||.|........||...|.
Mouse   535 EPSVI-PQREGDGPGIKDRPMDAERPGPELFDPSSCPGEWLSEPEWTLEGIRGSRAQGLPAHHPH 598

  Fly   961 PMSVPLQLPPSSSS 974
            |..     ||.::|
Mouse   599 PHG-----PPRTTS 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	125/349 (36%)
Hipk4	NP_001028487.2	Protein Kinases, catalytic domain	11..347	CDD:473864	122/338 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..616		32/168 (19%)