Protein Alignment mnb and Dyrk3

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_663483.1
• Gene: Dyrk3 / 226419
• MGIID: 1330300
• Length: 586
• Species: Mus musculus
• Alignment Length: 515
• Identity: 182/515 - (35%)
• Similarity: 268/515 - (52%)
• Gaps: 90/515 - (17%)

  Fly   209 SSPS----SSSEVRAMQARIPNHFREPASGPLRKLSV---DLIKTYKH------------INEVY 254
            |||:    ||..:.|::..:       :|.|.:.|.:   ..:|.|||            ..|:|
Mouse   111 SSPASQGKSSESLSAVKCNL-------SSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIY 168

  Fly   255 Y----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFG 315
            :    |||:      ||.....|       |.||||.:..||....:....|||:..:|||||||
Mouse   169 FVGPNAKKR------QGVIGGPN-------NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFG 220

  Fly   316 QVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCL 380
            ||.:.|||:.:.:||:|:::|:|.|..||..|:::||.:.:.|......::.:...|.:|||:|:
Mouse   221 QVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCM 285

  Fly   381 VFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS 445
            .|||||.:||:|::...|:|.|:.|.|||||.:..:|..|.  :..|||||||||||||.:..||
Mouse   286 AFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH--KNKIIHCDLKPENILLKHHGRS 348

  Fly   446 AIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNE 510
            |.|::||||||...|::|.||||||||:||::||.:|...||:||.||||.|:.||:|||.|.:|
Mouse   349 ATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDE 413

  Fly   511 VDQMNKIVEVLGMPPKYLLDQAHKTRKFFD----------KIVADGSYVL--KKNQNGRKYKPPG 563
            .||:..::|:|||||:.||:|:.:.:.|.:          ....||..||  .:::.|:|..|||
Mouse   414 GDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPG 478

  Fly   564 SRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKR--- 625
            |:.....|                ....||| |.:.:.|.|.:||..|:||..||:|.:..:
Mouse   479 SKDWATAL----------------KGCGDYL-FIEFLKRCLQWDPSARLTPAQALRHPWISKSTP 526

  Fly   626 ---TADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAP 682
               |.|:.........|       :...|.|......||   .||...:..:|.:|.:.|
Mouse   527 KPLTMDKVPGKRVVNPT-------NAFQGLGSKLPPVVG---IASKLKANLMSETSGSIP 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	145/356 (41%)
Dyrk3	NP_663483.1	Disordered. /evidence=ECO:0000250|UniProtKB:O43781	1..187		21/95 (22%)
		PKc_DYRK2_3	142..521	CDD:271126	161/410 (39%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43781	467..480		5/12 (42%)