DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and HIPK1

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001356735.1	Gene:	HIPK1 / 204851	HGNCID:	19006	Length:	1210	Species:	Homo sapiens

Alignment Length:	1107	Identity:	269/1107 - (24%)
Similarity:	421/1107 - (38%)	Gaps:	259/1107 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 FLPKSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGGS 168
            |.|.|...:.....|:...|....|          |.|.||:..        |||.|.      :
Human     8 FSPPSVSSSAFCSAKKLKIEPSGWD----------VSGQSSNDK--------YYTHSK------T 48

  Fly   169 VDAAQGSGSGGGR--QRHAPLY--GRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNH-- 227
            :.|.||..:...:  ..:.|.|  |..:.|   ||....|:....|..|::......::...|
Human    49 LPATQGQANSSHQVANFNIPAYDQGLLLPA---PAVEHIVVTAADSSGSAATSTFQSSQTLTHRS 110

  Fly   228 ---FREP--ASGPLRKL-------SVDLIKTYKHI---NEVYYAKKKRRAQQTQGDDDSSNKKER 277
               ..||  ..|..||.       ||.:|:.:..:   |.............|.....||.:.:.
Human   111 NVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDY 175

  Fly   278 KLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLN 342
            :|.       .|:.:.    ...:.||:...:|:|:||||.|.:....:..|||||:||...:..
Human   176 QLV-------QHEILC----SMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYAR 229

  Fly   343 QAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTR 407
            |.||||.:|..::..:|: :|..|:....|..:||.|||||:|..||||.|:...|..:.|...|
Human   230 QGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIR 293

  Fly   408 KFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSR 469
            ...||:.|||:.|.:  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||
Human   294 PILQQVATALMKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSR 356

  Fly   470 FYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHK 534
            :||:||::||:.:..|||||||||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||....|
Human   357 YYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTK 421

  Fly   535 TRKFFD----------KIVADGSYVLK---KNQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLD 584
            |.:||:          ::.....:.|:   |::..|||.   ...|.|:  :.:.|...|...|.
Human   422 TTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYI---FNCLDDMAQVNMSTDLEGTDMLA 483

  Fly   585 EPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF------------------------KR 625
            |.    :|..::.||:.:||..|...|:||...|.|.|.                        ||
Human   484 EK----ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKR 544

  Fly   626 ---------------TADEATNTS---------GAGATANAGAGGSGSSGAGGSSGGGVGGGLGA 666
                           |...|.|||         ......|..:..:.||.|..::       |..
Human   545 RVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAAT-------LSL 602

  Fly   667 SNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSS------------------------- 706
            :||....::..||..|   ::||...|.:..|.|:..|::
Human   603 ANSDVSLLNYQSALYP---SSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQ 664

  Fly   707 AAQQQQAMPLPLPLPLPL---PPLAGP-----GGASDGQCHGLL---MHSVAANAMNNFSALSLQ 760
            |..:....|:.:...:|:   .|.|.|     |..:.|.|..|:   :|...|.....::.....
Human   665 ATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTL 729

  Fly   761 SNAHPPPSLANSHHSTNSLGSLNHISPGST-------------GCHNNNSNSSNNNTRHSRLYGS 812
            |.|...|:|      .....::....||.|             |...:||.........:...|.
Human   730 SCAAGRPAL------VEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQ 788

  Fly   813 NMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPN----- 872
            .:.:....|:.|  |.:::|....::..:...:....|...|   |..:::.|.:|..|:
Human   789 QLADWRNAHSHG--NQYSTIMQQPSLLTNHVTLATAQPLNVG---VAHVVRQQQSSSLPSKKNKQ 848

  Fly   873 SVPYYGNMSSSSVAAAAAAAAAAASHLMMTDS--SVISASAAGGGQGGGNPGQNPVTPSAAAFLF 935
            |.| ..:.||..|..:...:...:|.|..|.|  |::                 ||.......:.
Human   849 SAP-VSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLV-----------------PVQDQHQPIII 895

  Fly   936 PSQPAGTLYGTALGSLSD-------LPLPMPL-PMS-----VPLQLPPSSSSSVS---------- 977
            |..|:..:....:.|.:|       .|....| |.|     |.:...|.|.||:|
Human   896 PDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA 960

  Fly   978 ----SGSASVGSGGVGVGVVGQRRHITGP-AAQVGISQSVGSGSSGSATGASSSDASSSSPMVGV 1037
                |||...|.|.|.....|.|..|..| ..|:| ..:|.:.:||..:..:...||.|....|.
Human   961 LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLG-DCTVATQASGLLSNKTKPVASVSGQSSGC 1024

  Fly  1038 CV 1039
            |:
Human  1025 CI 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	130/395 (33%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	125/337 (37%)
HIPK1	NP_001356735.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1103
		STKc_HIPK1	174..528	CDD:271130	128/374 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856		5/21 (24%)
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847		0/2 (0%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093		36/143 (25%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998		26/107 (24%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..974		16/64 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770