DRSC/TRiP Functional Genomics Resources

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Protein Alignment mnb and DYRK1A

DIOPT Version :9

Sequence 1:NP_728107.2 Gene:mnb / 32771 FlyBaseID:FBgn0259168 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_001387.2 Gene:DYRK1A / 1859 HGNCID:3091 Length:763 Species:Homo sapiens


Alignment Length:915 Identity:439/915 - (47%)
Similarity:532/915 - (58%) Gaps:192/915 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 SGGSVDAAQGS-----------GSG---GGRQRHAPLYG-----RFVDAEDLPATHRDVMHHHSS 210
            :||...|.:.|           .:|   .|:..|:..|.     ...|.:....::.|.:....:
Human     3 TGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLT 67

  Fly   211 PSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKK 275
            .....::..:|.|:|..||:||:.|||||||||||||||||||||||||||.||.|| ||||:||
Human    68 NQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQG-DDSSHKK 131

  Fly   276 ERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPF 340
            |||:|||||||||:|||:|||||::||||||||||||||||||||||..||..||||||||||.|
Human   132 ERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAF 196

  Fly   341 LNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNL 405
            ||||||||:|||:||:.|.|.|||||.||||||:|||||||||:|||||||||||||||||||||
Human   197 LNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNL 261

  Fly   406 TRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRF 470
            |||||||:|||||||:||||:|||||||||||||||||||||||||||||||||||||.||||||
Human   262 TRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRF 326

  Fly   471 YRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKT 535
            |||||||||:.||||||||||||||||||||||||||.||||||||||||||:||.::||||.|.
Human   327 YRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391

  Fly   536 RKFFDKIVADGSYVLKKNQNG-RKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDL 599
            ||||:|: .||::.|||.::| |:|||||:||||:|||||||||||||..|.||:|:||||||||
Human   392 RKFFEKL-PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDL 455

  Fly   600 ILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSSGAGGSSG 657
            ||||||:|||||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||.:|||||
Human   456 ILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSG 520

  Fly   658 GGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPL 722
                      .|:||...|.    ||.....:            ||..:||.|            
Human   521 ----------TSNSGRARSD----PTHQHRHS------------GGHFTAAVQ------------ 547

  Fly   723 PLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISP 787
                      |.|.:.|       :......|.|....|....|..:....|....  :..|::|
Human   548 ----------AMDCETH-------SPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE--TTFHVAP 593

  Fly   788 GSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNG 852
            .....|:::.|||:::..|             ||     ::|:                      
Human   594 QQNALHHHHGNSSHHHHHH-------------HH-----HHHH---------------------- 618

  Fly   853 HGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQG 917
            ||:       |...|...|.   .|.:.::||  :...:.....||..||..|..:.|::.....
Human   619 HGQ-------QALGNRTRPR---VYNSPTNSS--STQDSMEVGHSHHSMTSLSSSTTSSSTSSSS 671

  Fly   918 GGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSAS 982
            .||.|..         .:.::|                                    |::.:..
Human   672 TGNQGNQ---------AYQNRP------------------------------------VAANTLD 691

  Fly   983 VGSGG---VGVGVVGQRRHITGPAAQVGISQSVGSG-----SSGSATGASSSDASSSSPMVGVCV 1039
            .|..|   |.:.|....|..||.|.......|..:|     :.|..|....:| ...|||.||||
Human   692 FGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGAD-REESPMTGVCV 755

  Fly  1040 QQNPV 1044
            ||:||
Human   756 QQSPV 760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mnbNP_728107.2 PKc_DYRK1 289..628 CDD:271128 284/339 (84%)
S_TKc 303..623 CDD:214567 270/320 (84%)
DYRK1ANP_001387.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..57 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..136 17/21 (81%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 117..134 13/17 (76%)
PKc_DYRK1 148..484 CDD:271128 282/336 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..442 24/33 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..540 21/80 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..679 25/143 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..763 12/18 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155025
Domainoid 1 1.000 553 1.000 Domainoid score I246
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 721 1.000 Inparanoid score I632
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002707
OrthoInspector 1 1.000 - - otm41257
orthoMCL 1 0.900 - - OOG6_103522
Panther 1 1.100 - - O PTHR24058
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 1 1.000 - - X1406
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.780

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