Protein Alignment mnb and DYRK1A

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001387.2
• Gene: DYRK1A / 1859
• HGNCID: 3091
• Length: 763
• Species: Homo sapiens
• Alignment Length: 915
• Identity: 439/915 - (47%)
• Similarity: 532/915 - (58%)
• Gaps: 192/915 - (20%)

  Fly   165 SGGSVDAAQGS-----------GSG---GGRQRHAPLYG-----RFVDAEDLPATHRDVMHHHSS 210
            :||...|.:.|           .:|   .|:..|:..|.     ...|.:....::.|.:....:
Human     3 TGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLT 67

  Fly   211 PSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKK 275
            .....::..:|.|:|..||:||:.|||||||||||||||||||||||||||.||.|| ||||:||
Human    68 NQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQG-DDSSHKK 131

  Fly   276 ERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPF 340
            |||:|||||||||:|||:|||||::||||||||||||||||||||||..||..||||||||||.|
Human   132 ERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAF 196

  Fly   341 LNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNL 405
            ||||||||:|||:||:.|.|.|||||.||||||:|||||||||:|||||||||||||||||||||
Human   197 LNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNL 261

  Fly   406 TRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRF 470
            |||||||:|||||||:||||:|||||||||||||||||||||||||||||||||||||.||||||
Human   262 TRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRF 326

  Fly   471 YRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKT 535
            |||||||||:.||||||||||||||||||||||||||.||||||||||||||:||.::||||.|.
Human   327 YRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391

  Fly   536 RKFFDKIVADGSYVLKKNQNG-RKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDL 599
            ||||:|: .||::.|||.::| |:|||||:||||:|||||||||||||..|.||:|:||||||||
Human   392 RKFFEKL-PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDL 455

  Fly   600 ILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSSGAGGSSG 657
            ||||||:|||||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||.:|||||
Human   456 ILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSG 520

  Fly   658 GGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPL 722
                      .|:||...|.    ||.....:            ||..:||.|
Human   521 ----------TSNSGRARSD----PTHQHRHS------------GGHFTAAVQ------------ 547

  Fly   723 PLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISP 787
                      |.|.:.|       :......|.|....|....|..:....|....  :..|::|
Human   548 ----------AMDCETH-------SPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE--TTFHVAP 593

  Fly   788 GSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNG 852
            .....|:::.|||:::..|             ||     ::|:
Human   594 QQNALHHHHGNSSHHHHHH-------------HH-----HHHH---------------------- 618

  Fly   853 HGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQG 917
            ||:       |...|...|.   .|.:.::||  :...:.....||..||..|..:.|::.....
Human   619 HGQ-------QALGNRTRPR---VYNSPTNSS--STQDSMEVGHSHHSMTSLSSSTTSSSTSSSS 671

  Fly   918 GGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSAS 982
            .||.|..         .:.::|                                    |::.:..
Human   672 TGNQGNQ---------AYQNRP------------------------------------VAANTLD 691

  Fly   983 VGSGG---VGVGVVGQRRHITGPAAQVGISQSVGSG-----SSGSATGASSSDASSSSPMVGVCV 1039
            .|..|   |.:.|....|..||.|.......|..:|     :.|..|....:| ...|||.||||
Human   692 FGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGAD-REESPMTGVCV 755

  Fly  1040 QQNPV 1044
            ||:||
Human   756 QQSPV 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	284/339 (84%)
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..57		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		17/21 (81%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		13/17 (76%)
		PKc_DYRK1	148..484	CDD:271128	282/336 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		24/33 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		21/80 (26%)
		Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146	595..625		11/76 (14%)
		Disordered. /evidence=ECO:0000269|PubMed:29849146	596..679		25/143 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763		12/18 (67%)