DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and hpk-1

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_741761.1	Gene:	hpk-1 / 180695	WormBaseID:	WBGene00001994	Length:	846	Species:	Caenorhabditis elegans

Alignment Length:	948	Identity:	236/948 - (24%)
Similarity:	376/948 - (39%)	Gaps:	265/948 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 SVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPA 232
            |:..|.|:.|  ..::.||  .|..|.|.:.|..::::     .:||:..||:   ||   ..||
Worm    50 SIQKAPGTSS--DNEQRAP--KRRADEEAVNAVPKNLL-----TTSSTFARAV---IP---AAPA 99

  Fly   233 SGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDY-IIKNG 296
                                :..|..|...|.......::..: .|:..:|      :| :|||.
Worm   100 --------------------ISSANNKMAPQSVTATAKTTTNR-GKVSGEG------EYQLIKNE 137

  Fly   297 ---EKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRAD 358
               ..:.::||:...:|||:|||||||:.......|||||:|....:..|.||||.:|..::..:
Worm   138 VLCSPYGNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNEN 202

  Fly   359 AENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTP 423
            :| ::..|:....|..::|.|||||:|..||||.|:...|..:.||..|....|:.||||.|.:
Worm   203 SE-EFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKS- 265

  Fly   424 ELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLA 485
             |.:||.|||||||:|.:|::.  .:|::||||:....:.:.: |:|||:||:||::||:.::.:
Worm   266 -LGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNES 329

  Fly   486 IDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVAD----- 545
            ||||||||::.|:..|.||:.|.:|.||:..|::..|:||..:|:.|.|..:||.::.::
Worm   330 IDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHT 394

  Fly   546 ---GSYV-LK------------KNQNGRKYKPPGSRKLHDI----LGVETGGPGGRRLDEPGHSV 590
               |||. ||            |::..|||.   ...:.||    .|.|:         :|...:
Worm   395 NVGGSYYRLKTVEEYEASSSTAKSKETRKYI---FNVIDDISRVCYGFES---------DPVEHL 447

  Fly   591 SDYL---KFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSGSSGA 652
            .|.:   :|.|::.:||..:|..|:||...|:..|...|.....|.:.....|:.........|
Worm   448 CDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFVTMTHINGYNFANYVHEAHKRMEICRKPG- 511

  Fly   653 GGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPL- 716
                                    .:.|.|..|...||                        |:
Worm   512 ------------------------PAMATPYRAANVAT------------------------PIT 528

  Fly   717 PLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPP----PSLANSHHSTN 777
            |:..| |.|.|..|            |.:|... :|..:|.::     ||    |.|.|..|..:
Worm   529 PVEKP-PAPKLQQP------------MIAVLPQ-LNQIAATNI-----PPVPTQPDLTNLMHHYS 574

  Fly   778 SLGSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDP 842
            .:.:.                                        :||:.......|
Worm   575 QMAAA----------------------------------------TGSAATAAQFFY-------- 591

  Fly   843 PQMPPPPPNGHGRM------RVPAIMQL-QPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLM 900
            ..:||.|...:.::      |.|..:.| .|:...|..|| ...|..|.:.......||....::
Worm   592 QPLPPAPLFQYAQLHHPFAARPPHFLSLATPSHMVPQFVP-VPIMDPSMLQGQWPPGAAQQFAVL 655

  Fly   901 MTDSSVISASAAGGGQGGGNP-GQNPVTPSAAAFLFPSQPAGTLYGTAL-GSLSDLPLPMPLPMS 963
            ..|...:.|.     ||.... ...|.|.|...||..|.|:.|   ||. |:..::|.
Worm   656 ANDIMRVPAP-----QGINQMFASTPQTFSLPQFLSSSIPSAT---TAFNGNAPNIPF------- 705

  Fly   964 VPLQLPPSSSSSVSSGSA------------SVGSGGVGVGVVGQRRHITGPAAQV------GISQ 1010
                  |..:||.:.|:|            |:.:|.|.|..:..:.....||..|      ..|.
Worm   706 ------PEENSSWALGTAAQQQQQQAQRAQSMINGNVKVKPLAAQPKKNSPAPSVITLSSDEDSN 764

  Fly  1011 SVGSGSSGSA--TGASSSDASSSSPMVGVCVQQNPVVI 1046
            ..||.:|||.  |||.:...:.:.|| |..::...:::
Worm   765 GAGSSNSGSTTRTGAVNPVRNDTLPM-GNTIKTEDILV 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	131/373 (35%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	125/350 (36%)
hpk-1	NP_741761.1	PKc_like	147..483	CDD:304357	125/350 (36%)
hpk-1	NP_741761.1	S_TKc	147..483	CDD:214567	125/350 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910