Protein Alignment mnb and mbk-2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001023207.1
• Gene: mbk-2 / 178250
• WormBaseID: WBGene00003150
• Length: 817
• Species: Caenorhabditis elegans
• Alignment Length: 777
• Identity: 234/777 - (30%)
• Similarity: 336/777 - (43%)
• Gaps: 249/777 - (32%)

  Fly    31 AAAGGSFSSSIITSSSSSLNHHP--HN-----------------------GHHN----------- 59
            |||..|||.:   |||||.:|||  |:                       ||.|
 Worm    67 AAAPTSFSGA---SSSSSNHHHPVYHSQNSLPPNLLGSSQNSASSNSLVQGHRNPALGSGNTLTR 128

  Fly    60 -HHHP--------------------------------------PHYINYLAQIGCQHRVRNWPTN 85
             :|.|                                      ||.:||:......:....:|:.
 Worm   129 SYHQPSSTNSSTNNLYGPLGTISRDLKQSIRDISPPVINSSANPHLVNYVQTSSFDNGSYEFPSG 193

  Fly    86 GNQDQ----------ADDDDAGHQIISKFLPKSAWDTVLLDVKRDVDED-------------GDR 127
            ..|.|          |........:.|.  |:|: .:.||..::.|..:             ...
 Worm   194 QAQQQRRLGGSQQHLAPLQQTASSLYSN--PQSS-SSQLLGQQQAVRPNYAYQQSLPRQQHINSH 255

  Fly   128 DRDRVDGNVLMVQGSSSSSSRMKAERALYYTMS---------AYG-------SSGGSVDAAQGSG 176
            ......|.|.....|::..:.::|.:.:...::         |.|       ||.||.:::.|.|
 Worm   256 QTQAFFGTVRGPTNSTNIVTPLRASKTMIDVLAPVRDTVAAQATGLPNVGTSSSNGSSNSSSGVG 320

  Fly   177 SG----------GGRQRHAPLYGRFVDAEDLPATH--------RDVMH----------------- 206
            ||          ||..:|            |.|:|        .|:||
 Worm   321 SGGSGSLMTQSIGGPNKH------------LSASHSTLNTASTHDMMHSKIPKSPSNESLSRSHT 373

  Fly   207 ---------HHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVY-------- 254
                     |:|:..|:|..|...|             ::.....|:...|  ||:|
 Worm   374 SSSGGSQGGHNSNSGSNSGFRPEDA-------------VQTFGAKLVPFEK--NEIYNYTRVFFV 423

  Fly   255 --YAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQV 317
              :|||:      .|....:|       |.||||:|..|.:...:....|||:..:|||||||||
 Worm   424 GSHAKKQ------AGVIGGAN-------NGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQV 475

  Fly   318 VKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVF 382
            :||:||:.|.:||:|:::|:|.|..||..|:::|:.:.|.|::..:.|:.:..:|.:|||.|:.|
 Worm   476 IKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITF 540

  Fly   383 ELLSYNLYDLLRNTNFRGVSLNLTRKFAQQ--LCTALLFLSTPELNIIHCDLKPENILLCNPKRS 445
            ||||.|||:|::...|:|.||.|.||||..  ||..||    .:..:|||||||||:||....||
 Worm   541 ELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLL----QKNRLIHCDLKPENVLLKQQGRS 601

  Fly   446 AIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNE 510
            .||::||||||...||||.||||||||:|||:||.:|.:.||||||||||.|:.||.||..|.:|
 Worm   602 GIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDE 666

  Fly   511 VDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK----------IVADGSYVL--KKNQNGRKYKPPG 563
            .||:..|:|:|||||...|:.|.:.|.|...          .:.|||.||  .:::.|:...||.
 Worm   667 NDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPA 731

  Fly   564 SRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKR 625
            ||.....|                .::.|.| |.|.:.|.||:||:||:||..||:|.:.:|
 Worm   732 SRSWSTAL----------------KNMGDEL-FVDFLKRCLDWDPETRMTPAQALKHKWLRR 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	155/351 (44%)
mbk-2	NP_001023207.1	PKc_DYRK2_3	395..774	CDD:271126	171/427 (40%)