DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnb and Clk3

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_006243208.1	Gene:	Clk3 / 171305	RGDID:	621259	Length:	640	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	143/492 - (29%)
Similarity:	222/492 - (45%)	Gaps:	79/492 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 RQRHAPLYGRFVDAEDLPATHRDVMHHHS--------SPSSSSEVRAMQARIPNHFREPASGPLR 237
            |:...|...|....:.:|...|...|..|        |||...:... .:|..:..|....||.|
  Rat   189 RREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYG-SSRSRHRRRSRERGPYR 252

  Fly   238 KLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDR 302
                    |.||.:..:    |||.:........|.:..::......||.....:.:.|:...:|
  Rat   253 --------TRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQER 305

  Fly   303 YEIDSLIGKGSFGQVVKAYDHEE-QCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIV 366
            |||...:|:|:||:||:..||.. :..||:|||:|...:...|::|:.:|:.:...|.|||:..|
  Rat   306 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCV 370

  Fly   367 KLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCD 431
            .:...|.:..|:|:.||||..|.::.|:..||:...|...|..|.|||.||.||.  |..:.|.|
  Rat   371 LMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLH--ENQLTHTD 433

  Fly   432 LKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLG 479
            |||||||..|.                 |.::|::.||||:....:.....:.:|.||.|||:|.
  Rat   434 LKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE 498

  Fly   480 IQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF----- 539
            :.:....|:||:||||.|.:.|..||......:.:..:.::||..|.:::.:..|.:.|:
  Rat   499 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLV 563

  Fly   540 -DKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRM 603
             |:..:||.|| |:|     .||..|..|.|.|                    ::::..||:.||
  Rat   564 WDENSSDGRYV-KEN-----CKPLKSYMLQDSL--------------------EHVQLFDLMRRM 602

  Fly   604 LDFDPKTRVTPYYALQHNFF------KRTADEATNTS 634
            |:|||..|:|...||.|.||      :|:...:.|.|
  Rat   603 LEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPS 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	117/368 (32%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	112/343 (33%)
Clk3	XP_006243208.1	PHA03247	29..>162	CDD:223021
Clk3	XP_006243208.1	PKc_CLK3	292..622	CDD:271116	114/357 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740