Protein Alignment mnb and Hipk3

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_034564.2
• Gene: Hipk3 / 15259
• MGIID: 1314882
• Length: 1192
• Species: Mus musculus
• Alignment Length: 911
• Identity: 231/911 - (25%)
• Similarity: 351/911 - (38%)
• Gaps: 229/911 - (25%)

  Fly   265 TQGDDDSSNKKERKLYNDGYDDDNHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQC 327
            |.|:.|             |....|:.:  :||      .||:...:|:|:||||||.:......
Mouse   176 TSGEGD-------------YQLVQHEVLCSMKN------TYEVLDFLGRGTFGQVVKCWKRGTNE 221

  Fly   328 HVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDL 392
            .|||||:||...:..|.||||.:|..::..:|: :|..|:....|..|||.|||||:|..||||.
Mouse   222 IVAIKILKNHPSYARQGQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDF 285

  Fly   393 LRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSS 455
            |:...|..:.|.:.|...||:.|||..|.:  |.:||.|||||||:|.:|.|.  .:|::||||:
Mouse   286 LKQNKFSPLPLKVIRPVLQQVATALKKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA 348

  Fly   456 CQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVE 519
            ..:.:.:.. |:|||:||:||::||:.:..|||||||||::.|:..|.||:.|..|.||:..|.:
Mouse   349 SHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQ 413

  Fly   520 VLGMPPKYLLDQAHKTRKFF--DKIVADGSYVLK-----------KNQNGRKYKPPGSRKLHDIL 571
            ..|:|.:.||:...|:.:||  :..::...:.||           |::..|||.   ...|.||:
Mouse   414 TQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYI---FNSLDDIV 475

  Fly   572 GVET--GGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNF--FKRTAD---- 628
            .|.|  ...||..|.|.    :|..:|.:|:.:||..|...|:||...|.|.|  .|...|
Mouse   476 HVNTVMDLEGGDLLAEK----ADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHS 536

  Fly   629 -------------------EATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAV 674
                               |..|.|.........:.|:.:..|..:.       :|...|.:...
Mouse   537 NHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVASNGTAALAANFTK-------VGTLRSQALTT 594

  Fly   675 SSSSAAAPTAATAAATAAGSSG--------------SGSSVGGG---SSAAQQQQAMPLPLPLPL 722
            |:.|.........|.||....|              .|.....|   |.:.:....:||....|.
Mouse   595 SAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPA 659

  Fly   723 PLPPLAGPGGAS----DGQCHGLLMHS-------------------VAANAMNNFSALSLQSNAH 764
            ..|....||..|    .|:...:|:.:                   ..:..:.::..:...||.:
Mouse   660 VQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHY 724

  Fly   765 ----PPPSLAN----SHHSTNSLGSLNHI---SPGSTG----CHNNNSNSSNNNTRHSRLYGSNM 814
                |||.|.|    |.....|:| :.|:   .|.:|.    |.|.:::..|.|..||......:
Mouse   725 NSVMPPPLLTNQITLSAPQPISVG-IAHVVWPQPATTKKNKLCQNRSNSLQNTNIPHSAFISPKI 788

  Fly   815 VNMVGHHNSG----------SSNNHNSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSY 869
            :       ||          :.:||.|                   .|..
Mouse   789 I-------SGKEVEEVSCVDTQDNHTS-------------------EGEA--------------- 812

  Fly   870 APNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDS-----SVISASA-AGGGQGGGNPG------ 922
                    |....:||...::.:......:::.||     |||:.|: :...:....|.
Mouse   813 --------GTCREASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKG 869

  Fly   923 -------QNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQ-----LPPSSSSS 975
                   |:.:.......|  |.|..||..::.|..|..|...|..||...|     ....|.:|
Mouse   870 SLDCEACQSTLNIDRMCSL--SSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTS 932

  Fly   976 VSSGSASVGSGGVGVGVVGQRRHI---TGPAAQ--VG--ISQSVGSGSSGSATGASSSDASSSSP 1033
            .|||..|..:....|....|...:   .||.|:  ||  :...||..|..|.....::..|:..|
Mouse   933 DSSGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAVEPPVGRESGLSVDEHMANTDSTCQP 997

  Fly  1034 M 1034
            :
Mouse   998 L 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	134/360 (37%)
Hipk3	NP_034564.2	Protein Kinases, catalytic domain	196..525	CDD:473864	129/338 (38%)
		Interaction with AR. /evidence=ECO:0000250	767..921		34/204 (17%)
		Interaction with FAS. /evidence=ECO:0000269|PubMed:11034606	775..868		20/141 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..829		7/71 (10%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	832..988		37/157 (24%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	843..895		9/53 (17%)
		Interaction with UBL1. /evidence=ECO:0000250	847..857		2/9 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	889..943		17/53 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	956..1023		11/43 (26%)