Protein Alignment mnb and HIPK4

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_006723099.1
• Gene: HIPK4 / 147746
• HGNCID: 19007
• Length: 619
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 160/523 - (30%)
• Similarity: 237/523 - (45%)
• Gaps: 55/523 - (10%)

  Fly   301 DRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYI 365
            |.|:|..::|||:||:|.|.:.......|||||:||........:.|:|||..|...|.| :.::
Human     9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE-EAHV 72

  Fly   366 VKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHC 430
            ::....|.......||||||..||::..:..||..:.....|....|:.|||..|.  ||.|||.
Human    73 IRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK--ELAIIHA 135

  Fly   431 DLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIY---HYIQSRFYRSPEVLLGIQYDLAIDMWS 490
            |||||||:|.:..|.  .:|::||||:....:..|   .||||||||:||:|||:.:...:|:||
Human   136 DLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWS 200

  Fly   491 LGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIV---ADGSYVLKK 552
            |||::.|:|.|.||:.|.||.||:..|.|..|:|..:||..|.|...||.:..   |...:.||.
Human   201 LGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKS 265

  Fly   553 NQN---GRKYKPPGSRK--LHDILGVET--GGPGGRRLDEPGHSV----SDYLKFKDLILRMLDF 606
            :.:   ..|.:|...||  |..:..:||  ||....||..|....    :|.....:||.|||.:
Human   266 SADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTW 330

  Fly   607 DPKTRVTPYYALQHNFFK----RTADEATN---TSGAGATANAGAGGSGSSGAGGSSGG------ 658
            :...|::|..||:|.|..    |:|.|.|:   .|......:....|...:....:..|
Human   331 ESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCL 395

  Fly   659 ---GVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGS-SAAQQQQAMPLPLP 719
               ....|:|:...||.......|.....|...........:|..:.|.: :.|.....:||...
Human   396 AEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAA 460

  Fly   720 LPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNH 784
            :.....|.:||...       |..:|         |.|:.:..|..||:.:.|..:.::|..|:.
Human   461 ITGHHVPDSGPEPI-------LAFYS---------SRLAGRHKARKPPAGSKSDSNFSNLIRLSQ 509

  Fly   785 ISP 787
            :||
Human   510 VSP 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	128/349 (37%)
		S_TKc	303..623	CDD:214567	125/338 (37%)
HIPK4	XP_006723099.1	PKc_like	11..347	CDD:304357	125/338 (37%)
		S_TKc	11..347	CDD:214567	125/338 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740