Protein Alignment mnb and Dyrk1b

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001258299.1
• Gene: Dyrk1b / 13549
• MGIID: 1330302
• Length: 689
• Species: Mus musculus
• Alignment Length: 679
• Identity: 370/679 - (54%)
• Similarity: 443/679 - (65%)
• Gaps: 115/679 - (16%)

  Fly   163 GSSGGSVDAAQGSGSGGGRQRHAPL------------------YGRFVDAEDLPATHRDVMHHHS 209
            |.|||   .::|:|........||.                  :|.|..... |..|..|:
Mouse    27 GLSGG---GSRGAGCEKAPPGRAPAPGLTPLRPSEPTMAVPPGHGPFSGFPG-PQEHTQVL---- 83

  Fly   210 SPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNK 274
                 .:||.:..|:|..||:.||.||||||||||||||||||||||||||||||.. ..|||.|
Mouse    84 -----PDVRLLPRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAP-PQDSSTK 142

  Fly   275 KERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKP 339
            ||:|:.|.||||||||||:::||::|:||||||||||||||||||||||:.|..||||||||||.
Mouse   143 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKA 207

  Fly   340 FLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLN 404
            ||||||||::|||:||:.|.|.|||||.||||||:||||||||||||||||||||||:|||||||
Mouse   208 FLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLN 272

  Fly   405 LTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSR 469
            ||||.|||||||||||:||||:|||||||||||||||||||||||||||||||||||||.|||||
Mouse   273 LTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSR 337

  Fly   470 FYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHK 534
            ||||||||||..||||||||||||||||||||||||||.||||||::||||||:||..:|:||.|
Mouse   338 FYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPK 402

  Fly   535 TRKFFDKIVADGSYVLKKNQNGRK-YKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKD 598
            .||:|::: ..|.:.|::.:..|| |:.||:|:|.::|||:||||||||..|||||.:|||:|:|
Mouse   403 ARKYFERL-PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD 466

  Fly   599 LILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATAN----------AGAGGSGSSGAG 653
            |:||||:::|..|::|..||||.||:|||||||||..||::|:          :.:..|..|.:|
Mouse   467 LVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSG 531

  Fly   654 GSSG---------------GGVGGGLGASNSSSGAVSSSSAAAPTAA--------TAAATAAGSS 695
            ||||               ||.|..:.....:|..|..|....|.|.        .|..:|:...
Mouse   532 GSSGSSNDNRAYRYSNRYCGGPGPPITDCEMNSPQVLPSQPLRPWAGGDVPHKTHQAPISASTLP 596

  Fly   696 GSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGP----------GGASDGQCHGLLMHSVAANA 750
            |:|:            |..|||..|..|..|.:.|          |...|  |
Mouse   597 GTGA------------QLPPLPRCLGRPPSPTSPPPPELMDVSLVGSPPD--C------------ 635

  Fly   751 MNNFSALSLQSNAHPPPSLANSHHSTNSL 779
                        :.|||:.|..|.:.::|
Mouse   636 ------------SPPPPAPAPQHPAASAL 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	259/339 (76%)
		S_TKc	303..623	CDD:214567	247/320 (77%)
Dyrk1b	NP_001258299.1	PKc_DYRK1	157..496	CDD:271128	259/339 (76%)
		S_TKc	171..491	CDD:214567	247/320 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845485
Domainoid	1	1.000	554	1.000	Domainoid score	I247
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002707
OrthoInspector	1	1.000	-	-		otm43316
orthoMCL	1	0.900	-	-		OOG6_103522
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X1406
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730