Protein Alignment mnb and Dyrk1a

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_031916.1
• Gene: Dyrk1a / 13548
• MGIID: 1330299
• Length: 763
• Species: Mus musculus
• Alignment Length: 925
• Identity: 444/925 - (48%)
• Similarity: 532/925 - (57%)
• Gaps: 212/925 - (22%)

  Fly   165 SGGSVDAAQGSGSGGGRQRHAPLYGRFVD----AEDLPATHRDVMHHHSSPS-SSSEVRA----- 219
            :||...|.:.|.     .|.||.:.....    |..:|.:|:  ......|| |..:|.|
Mouse     3 TGGETSACKPSS-----VRLAPSFSFHAAGLQMAAQMPHSHQ--YSDRRQPSISDQQVSALPYSD 60

  Fly   220 ----------------MQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGD 268
                            :|.|:|..||:||:.|||||||||||||||||||||||||||.||.||
Mouse    61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQG- 124

  Fly   269 DDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKI 333
            ||||:|||||:|||||||||:|||:|||||::||||||||||||||||||||||..||..|||||
Mouse   125 DDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKI 189

  Fly   334 IKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNF 398
            |||||.|||||||||:|||:||:.|.|.|||||.||||||:|||||||||:||||||||||||||
Mouse   190 IKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNF 254

  Fly   399 RGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY 463
            ||||||||||||||:|||||||:||||:|||||||||||||||||||||||||||||||||||||
Mouse   255 RGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY 319

  Fly   464 HYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYL 528
            .|||||||||||||||:.||||||||||||||||||||||||||.||||||||||||||:||.::
Mouse   320 QYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384

  Fly   529 LDQAHKTRKFFDKIVADGSYVLKKNQNG-RKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSD 592
            ||||.|.||||:|: .||::.|||.::| |:|||||:||||:|||||||||||||..|.||:|:|
Mouse   385 LDQAPKARKFFEKL-PDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVAD 448

  Fly   593 YLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSS 650
            |||||||||||||:|||||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||
Mouse   449 YLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSS 513

  Fly   651 GAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMP 715
            .:|||||          .|:||...|.    ||.....:            ||..:||.|
Mouse   514 SSGGSSG----------TSNSGRARSD----PTHQHRHS------------GGHFAAAVQ----- 547

  Fly   716 LPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLG 780
                             |.|.:.|       :......|.|....|....|..:....|....
Mouse   548 -----------------AMDCETH-------SPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE-- 586

  Fly   781 SLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQM 845
            :..|::|.....|:::.|||:::..|             ||     ::|:
Mouse   587 TTFHVAPQQNALHHHHGNSSHHHHHH-------------HH-----HHHH--------------- 618

  Fly   846 PPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISAS 910
                   ||:       |...|...|.   .|.:.::||  :...:.....||..||..|..:.|
Mouse   619 -------HGQ-------QALGNRTRPR---VYNSPTNSS--STQDSMEVGHSHHSMTSLSSSTTS 664

  Fly   911 AAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSS 975
            ::......||.|..         .:.::|
Mouse   665 SSTSSSSTGNQGNQ---------AYQNRP------------------------------------ 684

  Fly   976 VSSGSASVGSGG---VGVGVVGQRRHITGPA--------AQVGISQSVGSGSSGSATGASSSDAS 1029
            |::.:...|..|   |.:.|....|..||.|        |..|.:..:..|......||...:
Mouse   685 VAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREE-- 747

  Fly  1030 SSSPMVGVCVQQNPV 1044
              |||.||||||:||
Mouse   748 --SPMTGVCVQQSPV 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	284/339 (84%)
Dyrk1a	NP_031916.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..61		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		17/21 (81%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		13/17 (76%)
		PKc_DYRK1	148..484	CDD:271128	282/336 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		24/33 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		21/80 (26%)
		Histidine-rich domain (HRD). /evidence=ECO:0000250|UniProtKB:Q13627	595..625		11/76 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..679		25/143 (17%)