DRSC/TRiP Functional Genomics Resources

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Protein Alignment mnb and Dyrk1a

DIOPT Version :9

Sequence 1:NP_728107.2 Gene:mnb / 32771 FlyBaseID:FBgn0259168 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_001106860.1 Gene:Dyrk1a / 13548 MGIID:1330299 Length:763 Species:Mus musculus


Alignment Length:925 Identity:444/925 - (48%)
Similarity:532/925 - (57%) Gaps:212/925 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 SGGSVDAAQGSGSGGGRQRHAPLYGRFVD----AEDLPATHRDVMHHHSSPS-SSSEVRA----- 219
            :||...|.:.|.     .|.||.:.....    |..:|.:|:  ......|| |..:|.|     
Mouse     3 TGGETSACKPSS-----VRLAPSFSFHAAGLQMAAQMPHSHQ--YSDRRQPSISDQQVSALPYSD 60

  Fly   220 ----------------MQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGD 268
                            :|.|:|..||:||:.|||||||||||||||||||||||||||.||.|| 
Mouse    61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQG- 124

  Fly   269 DDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKI 333
            ||||:|||||:|||||||||:|||:|||||::||||||||||||||||||||||..||..|||||
Mouse   125 DDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKI 189

  Fly   334 IKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNF 398
            |||||.|||||||||:|||:||:.|.|.|||||.||||||:|||||||||:||||||||||||||
Mouse   190 IKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNF 254

  Fly   399 RGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY 463
            ||||||||||||||:|||||||:||||:|||||||||||||||||||||||||||||||||||||
Mouse   255 RGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY 319

  Fly   464 HYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYL 528
            .|||||||||||||||:.||||||||||||||||||||||||||.||||||||||||||:||.::
Mouse   320 QYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384

  Fly   529 LDQAHKTRKFFDKIVADGSYVLKKNQNG-RKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSD 592
            ||||.|.||||:|: .||::.|||.::| |:|||||:||||:|||||||||||||..|.||:|:|
Mouse   385 LDQAPKARKFFEKL-PDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVAD 448

  Fly   593 YLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSS 650
            |||||||||||||:|||||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||
Mouse   449 YLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSS 513

  Fly   651 GAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMP 715
            .:|||||          .|:||...|.    ||.....:            ||..:||.|     
Mouse   514 SSGGSSG----------TSNSGRARSD----PTHQHRHS------------GGHFAAAVQ----- 547

  Fly   716 LPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLG 780
                             |.|.:.|       :......|.|....|....|..:....|....  
Mouse   548 -----------------AMDCETH-------SPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE-- 586

  Fly   781 SLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQM 845
            :..|::|.....|:::.|||:::..|             ||     ::|:               
Mouse   587 TTFHVAPQQNALHHHHGNSSHHHHHH-------------HH-----HHHH--------------- 618

  Fly   846 PPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISAS 910
                   ||:       |...|...|.   .|.:.::||  :...:.....||..||..|..:.|
Mouse   619 -------HGQ-------QALGNRTRPR---VYNSPTNSS--STQDSMEVGHSHHSMTSLSSSTTS 664

  Fly   911 AAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSS 975
            ::......||.|..         .:.::|                                    
Mouse   665 SSTSSSSTGNQGNQ---------AYQNRP------------------------------------ 684

  Fly   976 VSSGSASVGSGG---VGVGVVGQRRHITGPA--------AQVGISQSVGSGSSGSATGASSSDAS 1029
            |::.:...|..|   |.:.|....|..||.|        |..|.:..:..|......||...:  
Mouse   685 VAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREE-- 747

  Fly  1030 SSSPMVGVCVQQNPV 1044
              |||.||||||:||
Mouse   748 --SPMTGVCVQQSPV 760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mnbNP_728107.2 PKc_DYRK1 289..628 CDD:271128 284/339 (84%)
S_TKc 303..623 CDD:214567 270/320 (84%)
Dyrk1aNP_001106860.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..61 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..136 17/21 (81%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 117..134 13/17 (76%)
PKc_DYRK1 148..484 CDD:271128 282/336 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..442 24/33 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..540 21/80 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..679 25/143 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845489
Domainoid 1 1.000 554 1.000 Domainoid score I247
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 721 1.000 Inparanoid score I629
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002707
OrthoInspector 1 1.000 - - otm43316
orthoMCL 1 0.900 - - OOG6_103522
Panther 1 1.100 - - O PTHR24058
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 1 1.000 - - X1406
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.780

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