Protein Alignment mnb and mnb

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_003436034.2
• Gene: mnb / 1281364
• VectorBaseID: AGAMI1_007360
• Length: 1484
• Species: Anopheles gambiae
• Alignment Length: 1132
• Identity: 562/1132 - (49%)
• Similarity: 648/1132 - (57%)
• Gaps: 278/1132 - (24%)

  Fly    42 ITSSSSSLNHHPHNGHHNHHHPPHYINYLAQIGCQHRVRNWPTNGNQDQADDDDAGHQIISKFLP 106
            :.:::::|.:.|:......|||.|                      |.|......||.|.|:.:.
Mosquito   505 LPNTAATLGYQPYQPQQQSHHPAH----------------------QQQQHQSHIGHWIESEIIA 547

  Fly   107 KSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGGSVDA 171
            .|                                 |:|:||.|.|::| ...::|..:||...|:
Mosquito   548 SS---------------------------------SNSNSSTMLADKA-KQKLAAQFASGNVPDS 578

  Fly   172 AQGSGSGGGRQR-HAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGP 235
            .        ||| |||||||.|..|.|||.|||:.....||:||:::|||:||||..||:||:.|
Mosquito   579 T--------RQRHHAPLYGRLVTEEHLPAVHRDIHQRSISPTSSTDIRAMEARIPVLFRDPATAP 635

  Fly   236 LRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFL 300
            |||||||||||||||||||||||||||||||| :|:|:|||||||||||||:|||||||||||||
Mosquito   636 LRKLSVDLIKTYKHINEVYYAKKKRRAQQTQG-EDTSHKKERKLYNDGYDDENHDYIIKNGEKFL 699

  Fly   301 DRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYI 365
            ||||||||||||||||||||:||||:|.|||||||||||||||||||||||||||||||||||||
Mosquito   700 DRYEIDSLIGKGSFGQVVKAFDHEERCQVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYI 764

  Fly   366 VKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHC 430
            ||||||||||||||||||||||||:||||||||||||||||:|||||||||||||||||||||||
Mosquito   765 VKLKRHFMWRNHLCLVFELLSYNLFDLLRNTNFRGVSLNLTKKFAQQLCTALLFLSTPELNIIHC 829

  Fly   431 DLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCIL 495
            |||||||||||||||||||||||||||||||||.||||||||||||||||.||||||||||||||
Mosquito   830 DLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCIL 894

  Fly   496 VEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYK 560
            ||||||||||||.||.||:|:||||||||||::|||||||||||:|:.:||||||:|.||.||||
Mosquito   895 VEMHTGEPLFSGSNEADQINRIVEVLGMPPKHILDQAHKTRKFFEKLPSDGSYVLRKTQNQRKYK 959

  Fly   561 PPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKR 625
            ||||||||||||||||||||||..|||||||||||||||||||||:|||||||||||||||||||
Mosquito   960 PPGSRKLHDILGVETGGPGGRRHGEPGHSVSDYLKFKDLILRMLDYDPKTRVTPYYALQHNFFKR 1024

  Fly   626 TADEATNTSGA--------------------------------------------------GATA 640
            |:||:|||:..                                                  ...|
Mosquito  1025 TSDESTNTANTISSLSTSPSVSTQDQPSHGLSSLHQQQSSQPPSQQQTQPKAPQQQTLVLLAQPA 1089

  Fly   641 NAGAGG----------SGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSS 695
            ..|..|          |.||.:..||||.|.|        :||::.||     :.|..:||||..
Mosquito  1090 TVGTNGTHNNNNNNTNSSSSSSSNSSGGAVAG--------NGAIAGSS-----SVTGVSTAAGVI 1141

  Fly   696 GSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQ 760
            ..||:|.|.|:|.....   .||.:....|.....||...|       .|.||...|  :|:| .
Mosquito  1142 VPGSNVVGSSTAPTTSS---YPLAMDCDPPATVSLGGHHAG-------GSAAARYGN--TAVS-T 1193

  Fly   761 SNAHPPPSLANSHHSTNSL------------------GSLNHISP-----GSTGCHNNNSNSSNN 802
            |.|.|.||   .:|.:..|                  ||.:|:..     |..|.|.:.:.:|
Mosquito  1194 SGAAPAPS---HYHRSRYLAQQQQQQHQQAQQGQHLQGSASHLGSSALVVGGGGGHKSYAPAS-- 1253

  Fly   803 NTRHSRL---YGSNMVNMVG------HH----NSGSSNNHNSISYPHAMECDPPQMPP----PPP 850
                  |   .||:|.:.:|      ||    .|||...||.            .|||    ..|
Mosquito  1254 ------LPLDLGSHMASSLGGLVIPDHHAPAAMSGSFLAHNL------------SMPPGGGVVGP 1300

  Fly   851 NGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGG 915
            ...|.|.|...:     .|||.||      :.:.:.|||||::.|..          |....|||
Mosquito  1301 GSIGGMPVGGAV-----GYAPFSV------NEAMLMAAAAASSGAGG----------SVGPLGGG 1344

  Fly   916 QG----GGNPGQNPV-TPSAAAFLFPSQPAGTLYGTAL-------GSLSDLPLPMPLPMSVPLQL 968
            ..    ||..|...| |...|:.:.....|....|..:       |:.|.:
Mosquito  1345 NSLGVIGGPIGVGSVSTVGPASLVVGGSAAAVSVGVGVSSHHLIGGTGSSI-------------- 1395

  Fly   969 PPSSSSSVSSGSASVGSGGVGVGVVGQRRHITGPAAQVGIS--QSVGSGSSGSATGASS------ 1025
               |:||.||.|.:.|.||.|.|:.|.....|..|.....|  .|||||.||..:.:|:
Mosquito  1396 ---SNSSSSSSSTNGGGGGGGAGLAGPLGSGTVGAGSGSASGGSSVGSGGSGIVSSSSAKGHGRG 1457

  Fly  1026 -----SDASSSSPMVGVCVQQNPVVIH 1047
                 ||...||||||||||.:||:||
Mosquito  1458 PPGAPSDRDESSPMVGVCVQPSPVIIH 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	315/338 (93%)
mnb	XP_003436034.2	None