Protein Alignment mnb and Dyrk2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_061513458.1
• Gene: Dyrk2 / 1278112
• VectorBaseID: AGAMI1_002392
• Length: 673
• Species: Anopheles gambiae
• Alignment Length: 749
• Identity: 242/749 - (32%)
• Similarity: 344/749 - (45%)
• Gaps: 189/749 - (25%)

  Fly   136 VLMVQGSSSSSSRMKAERALYYT--MSAYGSSG-GSVDAAQGSGSGGGRQRHAPLYGRFVDAED- 196
            |:.:.....|..|::..:.||..  ....|.|| .:|..|..|.:|.|.        ..:||..
Mosquito    54 VIQLDSGKCSRERVQTTQQLYEANRPELAGLSGPRNVFRAGRSSNGTGT--------NMIDAHGN 110

  Fly   197 -LPATHRDVMHHHSSPSS----SSEVRAMQARIPNHFREPASG------PLRKLSVDLIKTYKHI 250
             ||..         ||||    ::|:...:..:|   ..||..      .|.......|:.||
Mosquito   111 ALPPL---------SPSSNNNTTTELENDKPMLP---MTPAKALDYHGVHLTDFEKQEIEKYK-- 161

  Fly   251 NEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDN-------HDYIIKNGEKFLDRYEIDSL 308
             |:||.....|         ..|.|.....|.|:||:|       ||:|..       ||||..:
Mosquito   162 -EIYYLGLDAR---------KINAKPGVGANSGFDDENGCYQKIVHDHICY-------RYEILEI 209

  Fly   309 IGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFM 373
            |||||||||::|.||:.:.:||||||:|||.|.:||.:||::|:.:.:.||:..::::.:..:|.
Mosquito   210 IGKGSFGQVIRALDHKTKQYVAIKIIRNKKRFHHQALVEVRILDELRKKDADGSHHVIHMLDYFY 274

  Fly   374 WRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENIL 438
            :|||||:.|||:|.|||:|::..|::|.||:|.::|...:...|.||.  ||:||||||||||:|
Mosquito   275 FRNHLCITFELMSLNLYELIKKNNYQGFSLSLIKRFCNSIVKCLRFLD--ELDIIHCDLKPENVL 337

  Fly   439 LCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEP 503
            |.....|.||::||||||...:.:|.||||||||||||:||..||.|||||||||||.|::||.|
Mosquito   338 LKQRGSSTIKVIDFGSSCFSDRTVYTYIQSRFYRSPEVILGYPYDKAIDMWSLGCILAELYTGYP 402

  Fly   504 LFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLH 568
            ||.|.|||:|:..|:|:||:|.|.:...|.:.|.|||   :.|......|..|||.| |||:.|.
Mosquito   403 LFPGENEVEQLACIMEILGVPSKEVFQLATRKRLFFD---SRGVPRCITNSKGRKRK-PGSKTLS 463

  Fly   569 DILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNT 633
            ..|          |.::        ..|.|.:.:.|::||..|:||..|.:|.:.:
Mosquito   464 QAL----------RCND--------TVFIDFVSKCLEWDPHKRMTPEQAARHEWLQ--------- 501

  Fly   634 SGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSG 698
                                                    ||:|.|           ..||....
Mosquito   502 ----------------------------------------VSASKA-----------YFGSKSKE 515

  Fly   699 SSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGG-----------ASD-------GQCHGLL-MH 744
            ||....:...:||::.|: .|..: ||.:..|..           |:|       ...|.|. :.
Mosquito   516 SSDTQLNFLHKQQRSQPM-TPNTI-LPEIKTPSNRTLRFTKERVKATDLETAQQQSSLHRLTNVR 578

  Fly   745 SVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSRL 809
            .|.|..:.|.|    .:|        :.||..:||.|....| ||:..||||    |||..|...
Mosquito   579 KVTATGLTNLS----NNN--------SGHHGISSLHSGGGGS-GSSSHHNNN----NNNHHHIST 626

  Fly   810 YGSNM-VNMVGHHNSGSS-----NNHNSISYPHA 837
            .||.. :|....:.|.:|     ::|:..:.||:
Mosquito   627 SGSTQTINGSSKYASSTSSAHHHHHHHGSAMPHS 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	154/338 (46%)
Dyrk2	XP_061513458.1	None