Protein Alignment mnb and Hipk

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_061496600.1
• Gene: Hipk / 1269819
• VectorBaseID: AGAMI1_007707
• Length: 1400
• Species: Anopheles gambiae
• Alignment Length: 1059
• Identity: 265/1059 - (25%)
• Similarity: 392/1059 - (37%)
• Gaps: 296/1059 - (27%)

  Fly   159 MSAYGSSG-GSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQA 222
            :|..|..| |...|..|.|.|||                           ...||.||...|...
Mosquito     7 ISTEGVCGCGECGATSGGGGGGG---------------------------GGVPSGSSGTVATSG 44

  Fly   223 RIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDD 287
            .:    ..|::|                      .|...::...|...::.:...|..:.|.|.|
Mosquito    45 AM----GAPSNG----------------------SKTAHSKVATGGGHANTQTSSKRSSSGADGD 83

  Fly   288 ----NHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEV 348
                .|:.:.    ....:||:...:|:|:||||||.:.......|||||:||...:..|.||||
Mosquito    84 YQLVQHEVLY----SLSAQYEVLEFLGRGTFGQVVKCWKKGTSDIVAIKILKNHPSYARQGQIEV 144

  Fly   349 KLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQL 413
            .:|..:::.:|: ::..|:....|..:||.|||||:|..||||.|:...|..:.|...|...||:
Mosquito   145 SILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQV 208

  Fly   414 CTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPE 475
            .||||.|.  :|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.: |:|||:||:||
Mosquito   209 LTALLKLK--QLGLIHADLKPENIMLVDPNRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPE 271

  Fly   476 VLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFD 540
            ::||:.:..|||||||||::.|:..|.||:.|.:|.||:..|.:..|:|.:::|:.|.||.|||.
Mosquito   272 IILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEYDQIRYISQTQGLPTEHMLNSASKTAKFFY 336

  Fly   541 KIVADGSYVL--------------KKNQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLDEPGHS 589
            :.| |.:|..              .|::..|||.   ...|.||  :.|.|...||:.|.|.
Mosquito   337 RDV-DSTYPFWRLKTPEEHEAETNNKSKEARKYI---FNCLDDIGQVNVPTDIEGGQLLAEK--- 394

  Fly   590 VSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF------------------------------- 623
             :|..:|.||:.|||..|.:.|:||..||.|:|.
Mosquito   395 -TDRREFIDLLKRMLTIDQERRITPGEALNHSFATLAHLVDYAHCNNVKASVQMMEVCRRTDSMI 458

  Fly   624 --------KRTADEATN-----TSGAGATANAGAGGSGSSGAGGSSG------GGVGGGLGASNS 669
                    ..||...||     |.....|.|..........|.....      ||...|...||:
Mosquito   459 HTYNLSVQPTTATLVTNFVPNTTENMTITFNNQVQRIVRERAPTYDNHLYQIYGGRNVGRQYSNA 523

  Fly   670 SSGA----VSSSSAAAPTAATAAATAAGSSGSGSSVGGGSS-------AAQQQQAMPLPLPLPLP 723
            ...|    :.||....|...|.      .|.:...|.||:|       ..||...:|:|:.:..|
Mosquito   524 RPDAFQHQLVSSILCPPGYQTM------PSPTKHVVVGGTSMQPPLQVPPQQYVNVPVPVSMVEP 582

  Fly   724 ------------LPPLAGPGGA-----------SDGQCHGLLMHSVAANAMNNFSALSLQSNAHP 765
                        .|.:|.|...           ..|..|.|::.|.        ..|.|: ..:|
Mosquito   583 SSGQRMLLTNAVQPNVAWPQSGRQVAIVPSWSQQPGPAHSLIVDSA--------PFLKLE-GIYP 638

  Fly   766 PP--SLANSHHSTNSLGSLNHI---SPGSTGCHNNNSNS---------SNNNTRHSRLYGSNMVN 816
            .|  ::..|||.......::|:   ...|...|:...|:         ..|...|.|...|:|..
Mosquito   639 NPHLNIQTSHHEPKKESPVHHLVVRKYSSVSRHDKKENNQLSPVKKRVKENTPPHQRYNRSHMCP 703

  Fly   817 MVGHHNSG---------------SSNNHNSISYPHAMECDPPQMPP-PPPNGHGRMRVPAIMQLQ 865
            .  :|::|               ||::..|..|....:....|... |..:|..:|:.|.:.|.|
Mosquito   704 Q--YHDNGTGSGATAGSSSAVASSSSSSTSAFYQQQQQQQQQQQSQVPSTSGSQQMQAPPVQQAQ 766

  Fly   866 PNSYAPNSVPYYGNMSSSSVAAAAAAAAAAA---------SHLMMTDSS-VISASAAG------- 913
            ..:..|....::.:..|......|:.::.:.         .|....||| .||...||
Mosquito   767 AQAQVPAPQHHHHHHHSQQQPQLASGSSGSGGHHSHHHQQQHYQPVDSSGPISGGGAGNLHHSSS 831

  Fly   914 -----GGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSS 973
                 ||.|.|..|.:.|....:..:..|......:|                          ||
Mosquito   832 STSSYGGSGSGGAGGSSVVMGGSGNIHHSGSGHHHHG--------------------------SS 870

  Fly   974 SSV--SSGSASVGSGGVGVGVVGQRRHITGPAAQVGISQSVGSGSSGSATGASSSDA----SSSS 1032
            ..:  ..|.|..|.|| |.|..|...|              |.|.|||..|:|....    .:.|
Mosquito   871 GHIHHGHGHAHHGGGG-GAGHHGSSHH--------------GHGGSGSYGGSSKQQTITIHDTPS 920

  Fly  1033 PMVGVCV----QQNPVVIH 1047
            |...:.:    .::|.|.|
Mosquito   921 PTAVITISDSEDESPEVKH 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	137/396 (35%)
Hipk	XP_061496600.1	None