Protein Alignment mnb and CLK3

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_003983.2
• Gene: CLK3 / 1198
• HGNCID: 2071
• Length: 490
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 137/466 - (29%)
• Similarity: 212/466 - (45%)
• Gaps: 90/466 - (19%)

  Fly   182 QRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKT 246
            :..:|.:|     ||           :..||.|...|..:.|          ||.|        |
Human    73 EERSPSFG-----ED-----------YYGPSRSRHRRRSRER----------GPYR--------T 103

  Fly   247 YKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGK 311
            .||.:..:    |||.:........|.:..::......||.....:.:.|:...:||||...:|:
Human   104 RKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGE 164

  Fly   312 GSFGQVVKAYDHEE-QCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWR 375
            |:||:||:..||.. :..||:|||:|...:...|::|:.:|:.:...|.|||:..|.:...|.:.
Human   165 GTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFH 229

  Fly   376 NHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLC 440
            .|:|:.||||..|.::.|:..||:...|...|..|.|||.||.||.  |..:.|.||||||||..
Human   230 GHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLH--ENQLTHTDLKPENILFV 292

  Fly   441 NP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDM 488
            |.                 |.::|::.||||:....:.....:.:|.||.|||:|.:.:....|:
Human   293 NSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDV 357

  Fly   489 WSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF------DKIVADGS 547
            ||:||||.|.:.|..||......:.:..:.::||..|.:::.:..|.:.|:      |:..:||.
Human   358 WSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGR 422

  Fly   548 YVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRV 612
            || |:|     .||..|..|.|.|                    ::::..||:.|||:|||..|:
Human   423 YV-KEN-----CKPLKSYMLQDSL--------------------EHVQLFDLMRRMLEFDPAQRI 461

  Fly   613 TPYYALQHNFF 623
            |...||.|.||
Human   462 TLAEALLHPFF 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	116/359 (32%)
CLK3	NP_003983.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..138		19/102 (19%)
		PKc_CLK3	142..472	CDD:271116	114/357 (32%)