Protein Alignment mnb and Dyrk4

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_011239406.1
• Gene: Dyrk4 / 101320
• MGIID: 1330292
• Length: 685
• Species: Mus musculus
• Alignment Length: 479
• Identity: 179/479 - (37%)
• Similarity: 251/479 - (52%)
• Gaps: 60/479 - (12%)

  Fly   273 NKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNK 337
            |....|.....:||::..|:....:....|||:..:|||||||||.|..||:....||:|||:||
Mouse   242 NVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNK 306

  Fly   338 KPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVS 402
            |.|.:||.:|:|:||.:.|.|.:|.:.:|.:|..|.:|||||:.||||..|||:|::|.:|.|.:
Mouse   307 KRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFN 371

  Fly   403 LNLTRKFAQQL--CTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHY 465
            |::.|:|...:  |..:|::.    .|||||||||||:|....:..:|::||||||...|::|.|
Mouse   372 LSIVRRFTFSILKCLHMLYVE----KIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTY 432

  Fly   466 IQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLD 530
            |||||||||||:||..|::||||||||||:.|::||.|||.|.|||:|:..|:||||:||.:...
Mouse   433 IQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQ 497

  Fly   531 QAHKTRKFFDKIVADGSYVLKKNQN----GRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVS 591
            .|.:.:.|||      |..|.||.|    |::|  |.|:.|..:                   |.
Mouse   498 TASRRQVFFD------SKGLPKNINNNRGGKRY--PDSKDLTMV-------------------VK 535

  Fly   592 DY-LKFKDLILRMLDFDPKTRVTPYYALQH-------NFFKRTADEATNTSGAGATANAGAGGS- 647
            .| ..|.|.:.|.|.::|..|:||..||:|       .|..|...:.....||..::......:
Mouse   536 TYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWIHEPRKFKPRPKPQILRKPGASISSEISTEKAE 600

  Fly   648 ---GSSGAGGSSGGGVGGGLGAS-----NSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGG 704
               .|.|....:.......|...     .:|....||....|.|......|.|  ||...:|.|.
Mouse   601 EQQASKGKKDEATKETTDKLKDEAEKHLENSGKQQSSVEHTADTIQLPHLTEA--SGKSETVAGS 663

  Fly   705 S-SAAQQQQAMPLPLPLPLPLPPL 727
            . ||.||..:.|....:   |||:
Mouse   664 EMSAEQQSTSSPKSTNI---LPPI 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	151/352 (43%)
Dyrk4	XP_011239406.1	PKc_DYRK4	228..568	CDD:271127	153/356 (43%)