Protein Alignment mnb and HIPK3

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_047282179.1
• Gene: HIPK3 / 10114
• HGNCID: 4915
• Length: 1233
• Species: Homo sapiens
• Alignment Length: 953
• Identity: 245/953 - (25%)
• Similarity: 367/953 - (38%)
• Gaps: 221/953 - (23%)

  Fly   169 VDAAQGSGSGGGRQRH--APLYG------RFVDAED---LPATHRDVMHHHSSPSSSSEVRAMQA 222
            |.|||      .:|.|  ||..|      .|::...   |.....::.:|.|:.....|:..:.|
Human   112 VIAAQ------AQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPA 170

  Fly   223 RIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDD 287
            .:..:...|.:                   |..|....:...|.|:.|             |...
Human   171 MLQTNMGNPVT-------------------VVTATTGSKQNCTTGEGD-------------YQLV 203

  Fly   288 NHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKL 350
            .|:.:  :||      .||:...:|:|:||||||.:.......|||||:||...:..|.||||.:
Human   204 QHEVLCSMKN------TYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSI 262

  Fly   351 LEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCT 415
            |..::..:|: :|..|:....|..|||.|||||:|..||||.|:...|..:.|.:.|...||:.|
Human   263 LARLSTENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVAT 326

  Fly   416 ALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVL 477
            ||..|.:  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::
Human   327 ALKKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEII 389

  Fly   478 LGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK- 541
            ||:.:..|||||||||::.|:..|.||:.|..|.||:..|.:..|:|.:.||:...|:.:||.|
Human   390 LGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKE 454

  Fly   542 -IVADGSYVLK-----------KNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSV---- 590
             .::...:.||           |::..|||.   ...|.|:..|.|      .:|..|..:
Human   455 TDMSHSGWRLKTLEEHEAETGMKSKEARKYI---FNSLDDVAHVNT------VMDLEGSDLLAEK 510

  Fly   591 SDYLKFKDLILRMLDFDPKTRVTPYYALQHNF--FKRTAD------------------------- 628
            :|..:|..|:.:||..|...|:||...|.|.|  .|...|
Human   511 ADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCD 575

  Fly   629 -----------EATNTSGAGATANAGAGGSGSSGAGGSSGGGV---GGGLGASNSSSG---AVSS 676
                       ...::|.|..|||....|:..|.|..:|...|   |..|.|..:..|   |...
Human   576 TNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQ 640

  Fly   677 SSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGAS---DGQC 738
            :....|.|........|...|.|        .:....:||....|...|....||..|   .|:.
Human   641 TLIICPPAIQGIPATHGKPTSYS--------IRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRT 697

  Fly   739 HGLLM------------------HSVA-ANAMNNFSALSLQSNAH----PPPSLAN----SHHST 776
            ..:|:                  .||| ::.:.::..:...||.:    |.|.|.|    |....
Human   698 QQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQP 762

  Fly   777 NSLGSLNHI---SPGSTGCHNNNSNSSNNNTRHSRLY---GSNMVNMVGHHNSGSSNNHNSISYP 835
            .|:| :.|:   .|.:|   ..|....|.......:.   |...:|.....||..:.|     .|
Human   763 VSVG-IAHVVWPQPATT---KKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTN-----IP 818

  Fly   836 HAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASH-- 898
            |:....|..:     ||.....|..| :.|.|.   ||.....|...:|:...:.::.:....
Human   819 HSAFISPKII-----NGKDVEEVSCI-ETQDNQ---NSEGEARNCCETSIRQDSDSSVSDKQRQT 874

  Fly   899 LMMTDS-----SVISASAAGG--------------GQGGGNPGQNPVTPSAAAFLFPSQPAGTLY 944
            :::.||     |||:.|:...              |.......|:.:.......|  |.|..||.
Human   875 IIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSL--SSPDSTLS 937

  Fly   945 GTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGSGG 987
            .::.|..|..|...|..||...|   .||.....||.:..|.|
Human   938 TSSSGQSSPSPCKRPNSMSDEEQ---ESSCDTVDGSPTSDSSG 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	132/362 (36%)
HIPK3	XP_047282179.1	STKc_HIPK3	214..543	CDD:271131	127/340 (37%)
		MSCRAMM_ClfA	<832..1039	CDD:468110	34/155 (22%)