Protein Alignment mnb and dyrk2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_002937581.2
• Gene: dyrk2 / 100485120
• XenbaseID: XB-GENE-854514
• Length: 625
• Species: Xenopus tropicalis
• Alignment Length: 552
• Identity: 192/552 - (34%)
• Similarity: 280/552 - (50%)
• Gaps: 104/552 - (18%)

  Fly   192 VDAEDLPATHRDVMHHHSSPSSSSEVRAMQ--ARIPNHFREPASGPLRKLSVDLIKTYKH----- 249
            |....|.:|||       ...|||.:::.:  .::.:....|...  .|..:..:..::|
 Frog   146 VSERQLESTHR-------RQGSSSSLKSAEGITKLKSSSLTPEQA--MKQYMQKLTAFEHHEIFN 201

  Fly   250 INEVYY----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIG 310
            ..|:|:    |||:      ||.....|       |.|||||...|:....:....|||:..:||
 Frog   202 YPEIYFLGPNAKKR------QGVIGGPN-------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIG 253

  Fly   311 KGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWR 375
            |||||||||||||:...|||:|:::|:|.|..||..|:::||.:.:.|.:|...::.:..:|.:|
 Frog   254 KGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFR 318

  Fly   376 NHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLC 440
            ||:|:.|||||.|||:|::...|:|.||.|.||||..:...|..|.  :..|||||||||||||.
 Frog   319 NHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALH--KNRIIHCDLKPENILLK 381

  Fly   441 NPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLF 505
            ...||.||::||||||...||:|.||||||||:|||:||.:|.:.||||||||||.|:.||.||.
 Frog   382 QQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLL 446

  Fly   506 SGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK----------IVADGSYVLK--KNQNGRK 558
            .|.:|.||:..::|:||||.:.|||.:.:.:.||..          .:.|||.||.  :::.|:.
 Frog   447 PGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVVLNGGRSRRGKL 511

  Fly   559 YKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF 623
            ..|||||.....|         :..|:|        .|.|.:.:.|::||..|:||..||:|::.
 Frog   512 RGPPGSRDWVTAL---------KGCDDP--------LFLDFLTQCLEWDPSLRMTPSQALRHHWL 559

  Fly   624 KR-----TADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPT 683
            :|     ...|..:|.                               ....|:||::|.|...||
 Frog   560 RRRLPKPPTGEKISTK-------------------------------RITESTGAITSISKLPPT 593

  Fly   684 AATAAATAAGSSGSGSSVGGGSSAAQQQQAMP 715
            :.:||......    :.:...:...||:..:|
 Frog   594 SGSAAKLRTNL----TQITDANGNIQQRTVLP 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	153/355 (43%)
dyrk2	XP_002937581.2	PKc_DYRK2_3	180..559	CDD:271126	169/412 (41%)