Protein Alignment mnb and dyrk1a.2

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_012821525.1
• Gene: dyrk1a.2 / 100145447
• XenbaseID: XB-GENE-5760738
• Length: 745
• Species: Xenopus tropicalis
• Alignment Length: 710
• Identity: 409/710 - (57%)
• Similarity: 476/710 - (67%)
• Gaps: 71/710 - (10%)

  Fly   165 SGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRA---------- 219
            ||.|......|.|.......||.  .||..|    .:....|.| :|.||.:..|
 Frog    44 SGSSTGCKSSSSSSSSFCLAAPF--AFVPTE----ANMSSQHSH-APFSSLQSMADHQQVLPDMT 101

  Fly   220 -MQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDG 283
             :|.|||..||:.|:.||||||||||||||||||||||||||||||.. .:|||.|||||::|||
 Frog   102 ILQRRIPLTFRDSAAAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQVP-PEDSSTKKERKVFNDG 165

  Fly   284 YDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEV 348
            :||||:|||:|||||::|||||||||||||||||||||||.:|..||||||||||.||||||||:
 Frog   166 FDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDHHDQEWVAIKIIKNKKAFLNQAQIEL 230

  Fly   349 KLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQL 413
            :|||:||:.|.|.|||||.||||||:|||||||||||||||||||||||||||||||||||||||
 Frog   231 RLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQL 295

  Fly   414 CTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLL 478
            |||||||:||||:|||||||||||||||||||||||||||||||||||||.||||||||||||||
 Frog   296 CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 360

  Fly   479 GIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIV 543
            |:.||||||||||||||||||||||||||.||||||||||||||.||.::||||.|.||:|||:
 Frog   361 GMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGTPPNHMLDQAPKARKYFDKL- 424

  Fly   544 ADGSYVLKKNQNGRK-YKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFD 607
            .:|::.:|||::.:| ||.||:|:||::||||||||||||..|.|||.|||||||||||||||:|
 Frog   425 PEGTWTVKKNKDLKKDYKVPGTRRLHEVLGVETGGPGGRRAGEQGHSPSDYLKFKDLILRMLDYD 489

  Fly   608 PKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSG 672
            ||||:||:|||||||||:|.||.||||.:.:|:.|......:|..  ||....||..|:||.:..
 Frog   490 PKTRITPFYALQHNFFKKTTDEGTNTSNSNSTSPAMDHSHSTSTT--SSVSSSGGSSGSSNDNRN 552

  Fly   673 AVSS----SSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLP-LPLPLPPLAGPGG 732
            ...|    :||.|.|.....:..|.|........||........:.|..|| .|.|..|....|.
 Frog   553 YRYSNRYYNSAVAHTDYEMQSPQAHSQQQIRLWAGGDVPITNSDSYPQILPHKPTPSQPQHFHGN 617

  Fly   733 ASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNS 797
             .....|.|..|   .|..:....|...|:...|.|:      ..|||            |.:..
 Frog   618 -EPHHPHPLYHH---VNRPHYHRQLITSSSPQIPESM------ELSLG------------HRHPQ 660

  Fly   798 NSSNNNTRHSRL----YGSNMVNM----------VGHHNSG-------SSNNHNSISYPH 836
            :||:.:..|..|    :||:.:::          .||::||       |||..:.:..||
 Frog   661 SSSSLHPHHPSLDCTPFGSSNLHLGVSAFRTRTVSGHNDSGVPLNYPYSSNTSSMVGPPH 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	282/339 (83%)
		S_TKc	303..623	CDD:214567	268/320 (84%)
dyrk1a.2	XP_012821525.1	PKc_DYRK1	171..510	CDD:271128	282/339 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	551	1.000	Domainoid score	I248
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	730	1.000	Inparanoid score	I611
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002707
OrthoInspector	1	1.000	-	-		otm48465
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060