Protein Alignment mnb and dyrk3

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001108400.2
• Gene: dyrk3 / 100141364
• ZFINID: ZDB-GENE-080219-31
• Length: 582
• Species: Danio rerio
• Alignment Length: 647
• Identity: 210/647 - (32%)
• Similarity: 292/647 - (45%)
• Gaps: 138/647 - (21%)

  Fly   121 VDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERAL--------YYTMSAYGSSGGSVDAAQGSGS 177
            |::|.|.:.....|...:.:.:......||..:|:        |....:|......|....|:..
Zfish    32 VNQDADVNGQSPSGLPPLPKHTGVIKPTMKDHQAIRGGQMKVKYVYEDSYNRKLNGVSQHNGTSQ 96

  Fly   178 GGGRQRHAPLYGRFVDAEDLPA--THRDVMHHHSSPSSSSEVRAMQARIP--------NHFREPA 232
                          |.|:..||  ..|.|..:.|..||.|..:..:...|        .|.::
Zfish    97 --------------VPAKPPPAISKERSVDSNSSVKSSESSTKVTKLGSPMTPEQALKQHRQQ-- 145

  Fly   233 SGPLRKLSVDLIKTYKHINEVYY----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYII 293
               :..|....|..|   :|:|:    |||:   |...|..:          |.|||||...||.
Zfish   146 ---MTTLEQQEIHNY---SEIYFLGPNAKKR---QAVAGGTN----------NSGYDDDQGGYIH 191

  Fly   294 KNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRAD 358
            ...:....|||...:|||||||||.|.|||:.|.|||:||::|:|.|..||..|:::||.:.:.|
Zfish   192 VPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQD 256

  Fly   359 AENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTP 423
            ......:|.:..:|.:|||:|:.|||||.|||:|::...|:|.||.|.||||..:...|..|...
Zfish   257 KTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRH 321

  Fly   424 ELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDM 488
            :  |||||||||||||....||.||::||||||...||:|.||||||||:|||:||.:|.:.|||
Zfish   322 K--IIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDM 384

  Fly   489 WSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFD----------KIV 543
            ||.||||.|:.||.|||.|.:|.||:..::|:|||||..||:||.:.:.|..          ..:
Zfish   385 WSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVSTL 449

  Fly   544 ADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDP 608
            ::|:.||    ||.:     ||:     |...|.||.:..........| ..|.|.:.:.||:||
Zfish   450 SNGTIVL----NGSR-----SRR-----GKMRGAPGSKEWGTALKGCED-ATFIDFLKKCLDWDP 499

  Fly   609 KTRVTPYYALQHNF-FKRTADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSG 672
            .||:||..||:|.: :||....|..                                |.......
Zfish   500 STRMTPVQALRHPWLYKRLPKPAPG--------------------------------GEKTVLPK 532

  Fly   673 AVSSSSAAAPTAATAAATAAGSSGS-------GSSVGGGSSAAQQQQAMPLPLPLPLPLPPL 727
            .:|..|.:.||..:......||:.:       |.|.|.              :|....||.|
Zfish   533 RISEHSTSFPTIISKVPPVMGSTNNKLRTTMMGDSTGS--------------IPFRTVLPKL 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	156/349 (45%)
dyrk3	NP_001108400.2	PKc_DYRK2_3	135..514	CDD:271126	171/416 (41%)