Protein Alignment mnb and dyrk1aa

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001074158.1
• Gene: dyrk1aa / 100005019
• ZFINID: ZDB-GENE-050302-29
• Length: 737
• Species: Danio rerio
• Alignment Length: 910
• Identity: 436/910 - (47%)
• Similarity: 518/910 - (56%)
• Gaps: 227/910 - (24%)

  Fly   161 AYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRD---VMHHHSSPS-SSSEVRA-- 219
            ::.|:|..:||..       ...|.|    |.||....|..:.   :.::..:|. |:::|.|
Zfish    26 SFHSAGVQMDAQT-------PHSHPP----FSDAHPQGAADQSAAALPYNPQAPQPSATQVTADM 79

  Fly   220 --MQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYND 282
              :|.|:|..||:||:.||||||::|||||||||||||||||||.||.|| :|||||||||:|||
Zfish    80 VMLQRRMPQCFRDPATAPLRKLSIELIKTYKHINEVYYAKKKRRHQQGQG-EDSSNKKERKIYND 143

  Fly   283 GYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIE 347
            ||||||.|||:|||||::||||||||||||||||||||||..||..||||||||||.||||||||
Zfish   144 GYDDDNFDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIE 208

  Fly   348 VKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQ 412
            |:|||:||:.|.|.|||||.||||||:|||||||||:||||||||||||||||||||||||||||
Zfish   209 VRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQ 273

  Fly   413 LCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVL 477
            ||||||||:||||:|||||||||||||||||||||||||||||||||||||.|||||||||||||
Zfish   274 LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVL 338

  Fly   478 LGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKI 542
            ||:.||||||||||||||||||||||||||.||||||||||||||:||.::|:||.|.||||:|
Zfish   339 LGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARKFFEK- 402

  Fly   543 VADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFD 607
            :.|..:..||.::|::|||.||||||.|||||.|||||||..|.||:|:||||||||||||||:|
Zfish   403 MPDSMWCAKKTKDGKRYKPAGSRKLHSILGVEAGGPGGRRAGESGHAVADYLKFKDLILRMLDYD 467

  Fly   608 PKTRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSSGAGGSSGGGVGGGLG 665
            ||||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||.:|||||....|...
Zfish   468 PKTRIQPYYALQHSFFKKTADEGTNTSSSVSTSPALEQSQSSGTTSSTSSSSGGSSGTSTSGRAR 532

  Fly   666 A----SNSSSGAVSSSSAAA-------PTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLP 719
            :    .:..||....|:|.|       |.|..|...|.|..|.|.....|.:...|:....:|
Zfish   533 SDPTHQHRHSGGGHFSAAVAMDCHNLCPQARQAFVPALGWVGDGLQQASGETHPVQETTFHVP-- 595

  Fly   720 LPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNH 784
               |..|.|                                  .||     :.||
Zfish   596 ---PHQPKA----------------------------------LHP-----HQHH---------- 608

  Fly   785 ISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPP 849
                                               ||     ::|:                 ||
Zfish   609 -----------------------------------HH-----HHHH-----------------PP 616

  Fly   850 PNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGG 914
            |:|.|..|.      :|..|:|           |..|:...:......||.||.   :|:||:..
Zfish   617 PHGQGPARP------RPRLYSP-----------SHSASTQDSMEVTHGHLSMTS---LSSSASSS 661

  Fly   915 GQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSG 979
            .....:.|.:       .:.:.|:                |||..|                  |
Zfish   662 STSSSSTGNH-------HYAYQSR----------------PLPHGL------------------G 685

  Fly   980 SASVGSGGVGVGVVGQRRHITGPAAQVGISQSVGSGSSGSATGASSSDASSSSPMVGVCVQQNPV 1044
            ....||..:|:|.....|..|| .|.||:...:               ....|||.||||||:.|
Zfish   686 FGHSGSMTLGLGAFSNPRQETG-VAGVGLRPGL---------------EREESPMAGVCVQQSSV 734

  Fly  1045  1044
            Zfish   735  734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	280/338 (83%)
dyrk1aa	NP_001074158.1	PKc_DYRK1	151..488	CDD:271128	280/337 (83%)