DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6769 and ZNF622

DIOPT Version :9

Sequence 1:	NP_001259663.1	Gene:	CG6769 / 32770	FlyBaseID:	FBgn0030878	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_219482.1	Gene:	ZNF622 / 90441	HGNCID:	30958	Length:	477	Species:	Homo sapiens

Alignment Length:	480	Identity:	189/480 - (39%)
Similarity:	271/480 - (56%)	Gaps:	78/480 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHFTCLNCDARFASADVQRNHYKTDWHRYNLKRRVAQLPPVTAEEFQQRVLSARSATDAALEEQ 65
            |:.:||:.|...|..||:||.|||||||||||:|:||.:.|||||.||:||.:.|:..:.  |.:
Human     1 MATYTCITCRVAFRDADMQRAHYKTDWHRYNLRRKVASMAPVTAEGFQERVRAQRAVAEE--ESK 63

  Fly    66 NLSVYCHACRRQFASQKAHDNHLNSRKHKEL----------LARFEREQMTASGGSASTATSVCT 120
            ..:.||..|.::|||..|::|||.||:|.||          ......|:....|....:......
Human    64 GSATYCTVCSKKFASFNAYENHLKSRRHVELEKKAVQAVNRKVEMMNEKNLEKGLGVDSVDKDAM 128

  Fly   121 RSVVEQR-------------PHPA------LAAAAAGKG-----------RLAFAERVVK----- 150
            .:.::|.             |.||      :|....|:|           ||.:.|:..|
Human   129 NAAIQQAIKAQPSMSPKKAPPAPAKEARNVVAVGTGGRGTHDRDPSEKPPRLQWFEQQAKKLAKQ 193

  Fly   151 --ANNDEEMVDEDDDDFEDIEEEE----VDSDEWDKIPEN----------------PLTERDCLF 193
              .:::||..|.|.||:|||:.:|    .|::..|.:.|.                |:|  ||||
Human   194 QEEDSEEEEEDLDGDDWEDIDSDEELECEDTEAMDDVVEQDAEEEEAEEGPPLGAIPIT--DCLF 256

  Fly   194 CTHASEDLVENLKHMSVAHSFFIPDTEYCTDIEGLLYYLGEKVANYFICLFCNDRGKTFYSLDAV 258
            |:|.|..|::|:.||:..|||||||.||.:||:||:.||||||....|||:||::||:|||.:||
Human   257 CSHHSSSLMKNVAHMTKDHSFFIPDIEYLSDIKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAV 321

  Fly   259 RKHMIDKGHCQMLHEGVALAEYAEYYDYSSSYPDNNEGMDIDE-EVVPD----LLDGDEYQLVLP 318
            :.||.||.||::..:|.|..|:|::||:.|||||:.||.|.:: |.:|.    ..|.:..:|:||
Human   322 QAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDHKEGEDPNKAEELPSEKNLEYDDETMELILP 386

  Fly   319 SGAVIGHRSLLRYYKQRLRPERAVVIKKSDRKLHRVLSEYRALGWTQTQQLSAARKARDIHLMKR 383
            |||.:|||||:||||||....|||.:.|:.:.:.|||.:|||||||.:.. :|..:.||:..::|
Human   387 SGARVGHRSLMRYYKQRFGLSRAVAVAKNRKAVGRVLQQYRALGWTGSTG-AALMRERDMQYVQR 450

  Fly   384 VQSKWQMKLGCKANKL-QKHYRAQV 407
            ::|||.:|.|.|.|.. |.|:|.||
Human   451 MKSKWMLKTGMKNNATKQMHFRVQV 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6769	NP_001259663.1	C2H2 Zn finger	6..28	CDD:275371	12/21 (57%)
		zf-C2H2_jaz	70..94	CDD:288983	12/23 (52%)
		C2H2 Zn finger	71..93	CDD:275371	11/21 (52%)
		zf-C2H2_2	191..290	CDD:289522	54/98 (55%)
ZNF622	NP_219482.1	PTZ00448	<6..49	CDD:185627	27/42 (64%)
		C2H2 Zn finger	6..28	CDD:275371	12/21 (57%)
		zf-C2H2_jaz	68..91	CDD:403410	12/22 (55%)
		C2H2 Zn finger	69..91	CDD:275371	11/21 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..212		16/76 (21%)
		zf-C2H2_2	254..353	CDD:403839	54/98 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141888
Domainoid	1	1.000	127	1.000	Domainoid score	I5386
eggNOG	1	0.900	-	-		E1_KOG2785
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74377
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2504
Isobase	1	0.950	-	0	Normalized mean entropy	S2402
OMA	1	1.010	-	-		QHG55525
OrthoDB	1	1.010	-	-		D1383726at2759
OrthoFinder	1	1.000	-	-		FOG0003451
OrthoInspector	1	1.000	-	-		oto89568
orthoMCL	1	0.900	-	-		OOG6_101830
Panther	1	1.100	-	-	LDO	PTHR13182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1915
SonicParanoid	1	1.000	-	-		X2347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750