DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6769 and REH1

DIOPT Version :9

Sequence 1:	NP_001259663.1	Gene:	CG6769 / 32770	FlyBaseID:	FBgn0030878	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_013491.1	Gene:	REH1 / 851103	SGDID:	S000004379	Length:	432	Species:	Saccharomyces cerevisiae

Alignment Length:	463	Identity:	122/463 - (26%)
Similarity:	205/463 - (44%)	Gaps:	95/463 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTCLNCDARFASADVQRNHYKTDWHRYNLKRRVAQLPPVTAEEFQQRV-LSARSATDAALEEQNL 67
            |||..|..:|.::|:||.|.||:|||||||||:|.|||:.||:|.::: :|.:...:..::|...
Yeast     6 FTCNCCVIQFKTSDLQRYHMKTEWHRYNLKRRIANLPPIGAEQFAEKLQISEKEQAENQVDEFGF 70

  Fly    68 SVYCHACRRQFASQKAHDNHLNSRKHKE----LLARFERE-------QMTASGGSASTATSVCTR 121
            .|......:..|..:.....:.|::.::    ||.|.:|:       :..:..||.|:..|
Yeast    71 PVLKPVMNQSNALPQKQKKPIKSKRGRKVGTNLLKRKDRDIAKEKQNRSVSPSGSISSQLS---- 131

  Fly   122 SVVEQRPHPALAAAAAGKGRLAFAERVVKANNDEEMVDE----DDDDFE-DIEEEEVDSDEWDKI 181
                               .|.........:..|:.|.|    .|.::| ...:||:|..:....
Yeast   132 -------------------NLTVGTENTNTDYGEDTVSEYGFTSDSNYEYATSDEELDIADKPSD 177

  Fly   182 PEN-PLTERDCLFCTHASEDLVENLKHMSVAHSFFIPDTEYCTDIEGLLYYLGEKVANYFICLFC 245
            .|| .:|..:|::|...::::..|:|||...|..|||:..|..|:.|||.:|.:.:.....||.|
Yeast   178 KENEKITITECIYCGKDNKEVERNVKHMFSEHGLFIPERSYLIDLNGLLEFLIKMIVIDHNCLCC 242

  Fly   246 NDRGKTFYSLDAVRKHMIDKGHCQMLHEGVALAE-YAEYYDY---------------------SS 288
            |..|.   .|:::|.||..|.||::.:|.....: :|.:||:                     ||
Yeast   243 NFHGS---GLESIRAHMASKRHCRLPYETKEERQLFAPFYDFTYDDHSISKNLQNDRAITSKLSS 304

  Fly   289 SYPDNNEGMD--IDEEVVP---DL--------LDGDEYQLVLPSGAVIGHRSLLRYYKQRL--RP 338
            .|...|:..|  :|..:|.   |:        :|....:|.||:||.:|||:..|||:|.|  :|
Yeast   305 VYGAKNDEEDGEVDITLVSSENDINANYTTVSIDESGLELTLPTGARLGHRAGQRYYRQNLPSQP 369

  Fly   339 ---ERAVVIKKSDRKLHRVLSEYRALGWTQTQQLSAARKARDIHLMKRVQSKWQMKLGCKANKLQ 400
               |....|..:||::        ..|.|:.|.....:|.:.   :::.....|::...|....|
Yeast   370 NPNESRRTITAADRRM--------VSGVTEKQYKKGMKKMQQ---LEKNAINTQIRREIKRVNFQ 423

  Fly   401 KHYRAQVL 408
            .|||.::|
Yeast   424 THYRDELL 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6769	NP_001259663.1	C2H2 Zn finger	6..28	CDD:275371	9/21 (43%)
		zf-C2H2_jaz	70..94	CDD:288983	2/23 (9%)
		C2H2 Zn finger	71..93	CDD:275371	2/21 (10%)
		zf-C2H2_2	191..290	CDD:289522	34/120 (28%)
REH1	NP_013491.1	PTZ00448	<1..54	CDD:185627	27/47 (57%)
		C2H2 Zn finger	8..30	CDD:275371	9/21 (43%)
		zf-C2H2_2	188..285	CDD:403839	32/99 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341668
Domainoid	1	1.000	86	1.000	Domainoid score	I1872
eggNOG	1	0.900	-	-		E1_KOG2785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I961
Isobase	1	0.950	-	0	Normalized mean entropy	S2402
OMA	1	1.010	-	-		QHG55525
OrthoFinder	1	1.000	-	-		FOG0003451
OrthoInspector	1	1.000	-	-		otm46749
orthoMCL	1	0.900	-	-		OOG6_101830
Panther	1	1.100	-	-	LDO	PTHR13182
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2347
TreeFam	1	0.960	-	-
	14	13.710