DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6769 and Zfp622

DIOPT Version :9

Sequence 1:	NP_001259663.1	Gene:	CG6769 / 32770	FlyBaseID:	FBgn0030878	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_653106.1	Gene:	Zfp622 / 52521	MGIID:	1289282	Length:	476	Species:	Mus musculus

Alignment Length:	481	Identity:	190/481 - (39%)
Similarity:	274/481 - (56%)	Gaps:	81/481 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHFTCLNCDARFASADVQRNHYKTDWHRYNLKRRVAQLPPVTAEEFQQRVLSARSATDAALEEQ 65
            |:..||:.|...|..|::||.|||||||||||:|:||.:.|||||.||:||.:.|:..:||...:
Mouse     1 MAALTCITCRVAFRDAELQRAHYKTDWHRYNLRRKVAAMAPVTAEGFQERVRAQRAVAEAAEASK 65

  Fly    66 NLSVYCHACRRQFASQKAHDNHLNSRKHKELLARFEREQMTASG------------------GSA 112
            ..:.||.||.::||:..|::|||.||:|.||    ||:.:.|:.                  |..
Mouse    66 GAATYCTACGKKFATFNAYENHLGSRRHAEL----ERKAVRAASRRVELLNAKNLEKGLGADGVD 126

  Fly   113 STATSVCTRSVVEQRP--HPALA----------AAAAGKG-----------RLAFAERVVK---- 150
            ..|.:...:..::.:|  .|..|          |||..:|           ||.:.|:..|
Mouse   127 KDAVNAAIQQAIKAQPSTSPKKAPFVPTDECGRAAAGARGVPERDPTEKPPRLQWFEQQAKKLAK 191

  Fly   151 -------ANNDEEMVDEDDDDFEDIEEEE---------VDSDEWDKIPEN-------PLTERDCL 192
                   ...:||..|::|:|:|||:.::         .|.|..|...|.       |:|  |||
Mouse   192 QQWEDGEEEGEEEEEDDEDEDWEDIDSDDGLECEDPGVEDQDAEDAAAEESPPLGAIPIT--DCL 254

  Fly   193 FCTHASEDLVENLKHMSVAHSFFIPDTEYCTDIEGLLYYLGEKVANYFICLFCNDRGKTFYSLDA 257
            ||:|.|..||:|:.||:..|||||||.||.:|::||:.||||||....|||:||::||:|||.:|
Mouse   255 FCSHHSSSLVKNVAHMTKVHSFFIPDIEYLSDLKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEA 319

  Fly   258 VRKHMIDKGHCQMLHEGVALAEYAEYYDYSSSYPDNNEGMDID--EEVVPDLL---DGDEYQLVL 317
            |:.||.||.||::..:|.|..|:|::||:.|||||..||.|..  |.:..|.:   |.:..:|:|
Mouse   320 VQAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDYKEGQDPAELEALSTDKILECDDETMELIL 384

  Fly   318 PSGAVIGHRSLLRYYKQRLRPERAVVIKKSDRKLHRVLSEYRALGWTQTQQLSAARKARDIHLMK 382
            ||||.:|||||:||||||....|||.:.::.:.:.|||.:||||||..:.. :|..:.||:..::
Mouse   385 PSGARVGHRSLMRYYKQRFGLPRAVTVARNQKAVGRVLQQYRALGWMGSTG-AALMRERDMQYVQ 448

  Fly   383 RVQSKWQMKLGCKANKL-QKHYRAQV 407
            |::|||.:|:|.|.|.. |.|:||||
Mouse   449 RMKSKWMLKIGMKNNATKQMHFRAQV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6769	NP_001259663.1	C2H2 Zn finger	6..28	CDD:275371	11/21 (52%)
		zf-C2H2_jaz	70..94	CDD:288983	12/23 (52%)
		C2H2 Zn finger	71..93	CDD:275371	11/21 (52%)
		zf-C2H2_2	191..290	CDD:289522	54/98 (55%)
Zfp622	NP_653106.1	C2H2 Zn finger	6..28	CDD:275371	11/21 (52%)
		zf-C2H2_jaz	70..93	CDD:288983	12/22 (55%)
		C2H2 Zn finger	71..93	CDD:275371	11/21 (52%)
		Ntn_Asparaginase_2_like	87..>144	CDD:294423	13/60 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..243		23/105 (22%)
		zf-C2H2_2	253..352	CDD:289522	54/98 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831933
Domainoid	1	1.000	128	1.000	Domainoid score	I5339
eggNOG	1	0.900	-	-		E1_KOG2785
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74377
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2445
Isobase	1	0.950	-	0	Normalized mean entropy	S2402
OMA	1	1.010	-	-		QHG55525
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003451
OrthoInspector	1	1.000	-	-		oto93135
orthoMCL	1	0.900	-	-		OOG6_101830
Panther	1	1.100	-	-	LDO	PTHR13182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1915
SonicParanoid	1	1.000	-	-		X2347
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740