DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6769 and znf622

DIOPT Version :9

Sequence 1:	NP_001259663.1	Gene:	CG6769 / 32770	FlyBaseID:	FBgn0030878	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_017207527.1	Gene:	znf622 / 407703	ZFINID:	ZDB-GENE-050927-1	Length:	453	Species:	Danio rerio

Alignment Length:	456	Identity:	179/456 - (39%)
Similarity:	270/456 - (59%)	Gaps:	57/456 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTCLNCDARFASADVQRNHYKTDWHRYNLKRRVAQLPPVTAEEFQQRVLSARSATDAALEEQNLS 68
            :||::|..:|:..:|||.|||||||||||||:||.:||||||.||:|||:.|    ||.|:|:..
Zfish     3 YTCISCRVQFSDGEVQRAHYKTDWHRYNLKRKVADMPPVTAENFQERVLAQR----AAAEQQSQG 63

  Fly    69 -----VYCHACRRQFASQKAHDNHLNSRKH-----------KELLARFEREQMTASGGSASTA-T 116
                 .||..|.::|::..|:.||:.|.||           :|.:.|...:.:....|....| .
Zfish    64 GGHDVAYCATCNKKFSTDNAYTNHIQSNKHQQAEKKALATAQETVQRMNEKNLEKGAGLDKDAQN 128

  Fly   117 SVCTRSVVEQRPHPALAAAAAGK---------GRLAF----AERVVKANNDEEMVDEDDDDFEDI 168
            ....::|.||:.|....|....|         .||.:    |:::.|...:||  :|:::|:||:
Zfish   129 EAIQKAVKEQQRHTPSKATPTEKQVRERPDKPPRLQWFEQQAKKIAKEEGEEE--EEEEEDWEDV 191

  Fly   169 -EEEEVDSDEWDK------------IPENPLTERDCLFCTHASEDLVENLKHMSVAHSFFIPDTE 220
             |:||:|.|:.::            :....:|..|||||.|.|..|..|:.||:..|||||||.|
Zfish   192 DEDEEMDDDDEEEEEMEQDSTSGAALAPGSITVTDCLFCGHHSHSLSRNVTHMTKTHSFFIPDIE 256

  Fly   221 YCTDIEGLLYYLGEKVANYFICLFCNDRGKTFYSLDAVRKHMIDKGHCQMLHEGVALAEYAEYYD 285
            |..|:.||:.||||||....:||:||::||:|||.:||:.||.||.||::..:|.|..|:|::||
Zfish   257 YLVDLRGLMSYLGEKVGVGKVCLWCNEKGKSFYSTEAVQAHMTDKSHCKLFTDGDAALEFADFYD 321

  Fly   286 YSSSYPDNNEGMDID--EEVVPD----LLDGDEYQLVLPSGAVIGHRSLLRYYKQRLRPERAVVI 344
            :.|||||..:|:|::  :..:||    ..|.:..:|.|||||.||||||:||||||...:||:|.
Zfish   322 FRSSYPDAKDGVDVEMKDGELPDDKTVEFDDETLELTLPSGAKIGHRSLMRYYKQRFGVQRALVP 386

  Fly   345 KKSDRKLHRVLSEYRALGWT-QTQQLSAARKARDIHLMKRVQSKWQMKLGCKANKL-QKHYRAQV 407
            ..:.:.:.|||.:|:||||| ...:...:::.:|:..::|::|||.::.|...|.. |.|:||||
Zfish   387 AHNQKAVGRVLKQYKALGWTGDFGKGFVSQQQKDMQYVQRMKSKWMLRTGMGNNATKQTHFRAQV 451

  Fly   408 L 408
            :
Zfish   452 M 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6769	NP_001259663.1	C2H2 Zn finger	6..28	CDD:275371	11/21 (52%)
		zf-C2H2_jaz	70..94	CDD:288983	10/34 (29%)
		C2H2 Zn finger	71..93	CDD:275371	7/21 (33%)
		zf-C2H2_2	191..290	CDD:289522	52/98 (53%)
znf622	XP_017207527.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574781
Domainoid	1	1.000	124	1.000	Domainoid score	I5478
eggNOG	1	0.900	-	-		E1_KOG2785
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74377
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2454
OMA	1	1.010	-	-		QHG55525
OrthoDB	1	1.010	-	-		D1383726at2759
OrthoFinder	1	1.000	-	-		FOG0003451
OrthoInspector	1	1.000	-	-		oto41725
orthoMCL	1	0.900	-	-		OOG6_101830
Panther	1	1.100	-	-	LDO	PTHR13182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1915
SonicParanoid	1	1.000	-	-		X2347
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800