DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6769 and Zfp622

DIOPT Version :9

Sequence 1:	NP_001259663.1	Gene:	CG6769 / 32770	FlyBaseID:	FBgn0030878	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001009652.1	Gene:	Zfp622 / 294846	RGDID:	1309146	Length:	470	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	187/475 - (39%)
Similarity:	269/475 - (56%)	Gaps:	75/475 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHFTCLNCDARFASADVQRNHYKTDWHRYNLKRRVAQLPPVTAEEFQQRVLSARSATDAALEEQ 65
            |:.:||:.|...|..|::||.|||||||||||:|:||.:.|||||.||:||.:.|:..:.  |.:
  Rat     1 MATYTCITCRVAFRDAEMQRAHYKTDWHRYNLRRKVANMAPVTAEGFQERVRAQRAVAEE--ESK 63

  Fly    66 NLSVYCHACRRQFASQKAHDNHLNSRKHKEL----------LARFEREQMTASGGSASTATSVCT 120
            ..:.||..|.::||:..|::|||.||:|.||          ......|:....|....:......
  Rat    64 GTATYCTVCSKKFATFNAYENHLKSRRHVELEKKAVQAVSRQVEMMNEKNLEKGLGVDSVNKDAM 128

  Fly   121 RSVVEQ--RPHPALA---------------AAAAGKG-----------RLAFAERVVKA------ 151
            .:.::|  :..|:.:               |.|..:|           ||.:.|:..|.
  Rat   129 NAAIQQAIKAQPSTSPKKAPFMPTDESRRVAGAVRRGTPERDPTEKPPRLQWFEQQAKKLAKQQW 193

  Fly   152 NNDEEMVDEDDDDFEDI-------------EEEEVDSDEWDKIP---ENPLTERDCLFCTHASED 200
            ...||..:|||:|:|||             |||:.:..|.::.|   ..|:|  |||||:|.|..
  Rat   194 EESEEEGEEDDEDWEDIDSDDGLECENPGVEEEDAEDAEAEESPPLGAIPIT--DCLFCSHHSSS 256

  Fly   201 LVENLKHMSVAHSFFIPDTEYCTDIEGLLYYLGEKVANYFICLFCNDRGKTFYSLDAVRKHMIDK 265
            ||:|:.||:..|||||||.||.:|::||:.||||||....|||:||::||:|||.:||:.||.||
  Rat   257 LVKNVAHMTKVHSFFIPDIEYLSDLKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMNDK 321

  Fly   266 GHCQMLHEGVALAEYAEYYDYSSSYPDNNEGMDIDEEVVPDL-------LDGDEYQLVLPSGAVI 323
            .||::..:|.|..|:|::||:.|||||..||.|..|  :.||       .|.:..:|:|||||.:
  Rat   322 SHCKLFTDGDAALEFADFYDFRSSYPDYKEGQDPAE--IEDLSSEKILECDDETMELILPSGARV 384

  Fly   324 GHRSLLRYYKQRLRPERAVVIKKSDRKLHRVLSEYRALGWTQTQQLSAARKARDIHLMKRVQSKW 388
            |||||:||||||....|||.:.::.:.:.|||.:|||||||.:.. :|..:.||:..::|::|||
  Rat   385 GHRSLMRYYKQRFGLPRAVTVARNQKAVGRVLQQYRALGWTGSTG-AALMRERDMQYVQRMKSKW 448

  Fly   389 QMKLGCKANKL-QKHYRAQV 407
            .:|.|.|.|.. |.|:||||
  Rat   449 MLKTGMKNNATKQMHFRAQV 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6769	NP_001259663.1	C2H2 Zn finger	6..28	CDD:275371	11/21 (52%)
		zf-C2H2_jaz	70..94	CDD:288983	11/23 (48%)
		C2H2 Zn finger	71..93	CDD:275371	10/21 (48%)
		zf-C2H2_2	191..290	CDD:289522	54/98 (55%)
Zfp622	NP_001009652.1	C2H2 Zn finger	6..28	CDD:275371	11/21 (52%)
		zf-C2H2_jaz	68..91	CDD:288983	11/22 (50%)
		C2H2 Zn finger	69..91	CDD:275371	10/21 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..237		21/101 (21%)
		zf-C2H2_2	247..346	CDD:289522	54/98 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335606
Domainoid	1	1.000	128	1.000	Domainoid score	I5208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74377
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3228
OMA	1	1.010	-	-		QHG55525
OrthoDB	1	1.010	-	-		D1383726at2759
OrthoFinder	1	1.000	-	-		FOG0003451
OrthoInspector	1	1.000	-	-		oto96687
orthoMCL	1	0.900	-	-		OOG6_101830
Panther	1	1.100	-	-	LDO	PTHR13182
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2347
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910