DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp8 and Actr3

DIOPT Version :9

Sequence 1:	NP_573251.1	Gene:	Arp8 / 32769	FlyBaseID:	FBgn0030877	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001192314.1	Gene:	Actr3 / 74117	MGIID:	1921367	Length:	418	Species:	Mus musculus

Alignment Length:	550	Identity:	101/550 - (18%)
Similarity:	172/550 - (31%)	Gaps:	191/550 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LQHCVVD---NKNRLRVA--TPPQQLAHFNRSSQAEKVPAPSGQMADEPWLDREAPVLFDDRILR 166
            |..||||   ...:|..|  |.||.:.   .|..|.|..|..|..|     .|......||....
Mouse     5 LPACVVDCGTGYTKLGYAGNTEPQFII---PSCIAIKESAKVGDQA-----QRRVMKGVDDLDFF 61

  Fly   167 LG--AVDARNYDIHFPIQRGELNVHNEKGGSLQASMQHLERIWSYALEERLKIPLRKLGTHCAVL 229
            :|  |::...|...:||:.|.:    |....::..|:.:  |:.|...|.        ..|..:|
Mouse    62 IGDEAIEKPTYATKWPIRHGIV----EDWDLMERFMEQV--IFKYLRAEP--------EDHYFLL 112

  Fly   230 V---VNDVYVRRHLREFVTLLLRRLGFRRCFLVQDSV----ASTFGAGIG----YGCVVDIGAQK 283
            .   :|....|.:..|   ::.........::...:|    ||.....:|    .|.|:|.|...
Mouse   113 TEPPLNTPENREYTAE---IMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGV 174

  Fly   284 TSIACIEDGISQLDARVRLSYGGGDLDQVLLLLL--RKCGFPYRECNVQESYVDAHLLDELKEKF 346
            |.:..:.:|.........:...|.|:...:..||  |:.|.|     .::|...|   ..:||::
Mouse   175 THVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIP-----PEQSLETA---KAVKERY 231

  Fly   347 CHLNASVCGAQEKHFNLRKHNG-QWLR------------YTIQVGDEALMAPLALFHTELLNITG 398
            .:    ||....|.||....:| :|::            ::|.||.|..:.|...||.|..|
Mouse   232 SY----VCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERFLGPEIFFHPEFAN--- 289

  Fly   399 RTKAVFTQQAVQDQYDCEDCFDAEYLKETGRKNGVRGGDILQLSTSAGYQPRPQLPVTADDEELI 463
               ..|||                                               |::    |::
Mouse   290 ---PDFTQ-----------------------------------------------PIS----EVV 300

  Fly   464 VVDQDETISNCQSQLGAQTAGGQMNSNGCYHNGQGLVLPLDQAIIQSINRLSSYETKRKMFGSIL 528
                ||.|.||                           |:|              .:|.::.:|:
Mouse   301 ----DEVIQNC---------------------------PID--------------VRRPLYKNIV 320

  Fly   529 LVGSSAKLPGLAAWLEQRISQQVQS------------------EVNVLIKGMDAGMVAWKGAAIM 575
            |.|.|.........|::.:.:.|.:                  :|.|:...|....| |.|.:::
Mouse   321 LSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAV-WFGGSML 384

  Fly   576 SVLESARELWISQNDWQRHGLRVLRERSPF 605
            :......::..::.|::..|..:.|....|
Mouse   385 ASTPEFYQVCHTKKDYEEIGPSICRHNPVF 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp8	NP_573251.1	NBD_sugar-kinase_HSP70_actin	202..603	CDD:302596	73/444 (16%)
Actr3	NP_001192314.1	PTZ00280	2..417	CDD:240343	100/549 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900